Configuration Transitions of Free Circular DNA System Induced by Nicks
Joint Authors
Ji, Chao
Zhang, Lingyun
Wang, Pengye
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-08-03
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Nicks have important functions in the biological functions of DNA-mediated systems.
However, the configuration transitions of DNA molecules induced by the presence of nicks have not been quantitatively investigated.
This study aims to analyze the configuration transitions of free circular DNA system induced by nicks.
Using atomic force microscopy, two configuration states were observed in the free circular DNA system with different nick numbers.
To understand the transmission of torsional energy among DNA base pairs, we defined the effective length and nicking angle.
In the free DNA system, a torsional energy of 233 bp can be completely released by nicks.
Based on the experimental and quantitative results, we propose a physical mechanism to explain the configuration transitions of the free circular DNA system induced by nicks.
This study and the presented method are very useful in understanding the physical mechanism of nicks in DNA-mediated systems.
American Psychological Association (APA)
Ji, Chao& Zhang, Lingyun& Wang, Pengye. 2015. Configuration Transitions of Free Circular DNA System Induced by Nicks. Journal of Nanomaterials،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1069120
Modern Language Association (MLA)
Ji, Chao…[et al.]. Configuration Transitions of Free Circular DNA System Induced by Nicks. Journal of Nanomaterials No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1069120
American Medical Association (AMA)
Ji, Chao& Zhang, Lingyun& Wang, Pengye. Configuration Transitions of Free Circular DNA System Induced by Nicks. Journal of Nanomaterials. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1069120
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1069120