Dioscorea bulbifera Mediated Synthesis of Novel AucoreAgshell Nanoparticles with Potent Antibiofilm and Antileishmanial Activity
Joint Authors
Bellare, Jayesh
Ghosh, Sougata
Kale, Sangeeta
Jagtap, Soham
More, Piyush
Shete, Usha J.
Maheshwari, Neeraj O.
Rao, Shilpa J.
Kitture, Rohini
Patil, Shivprasad
Pal, Jayanta K.
Chopade, Balu A.
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-04-22
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Dioscorea bulbifera is a potent medicinal plant used in both Indian and Chinese traditional medicine owing to its rich phytochemical diversity.
Herein, we report the rapid synthesis of novel Au core Ag shell nanoparticles by D.
bulbifera tuber extract (DBTE).
Au core Ag shell NPs synthesis was completed within 5 h showing a prominent peak at 540 nm.
HRTEM analysis revealed 9 nm inner core of elemental gold covered by a silver shell giving a total particle diameter upto 15 nm.
Au core Ag shell NPs were comprised of 57.34 ± 1.01 % gold and 42.66 ± 0.97 % silver of the total mass.
Au core Ag shell NPs showed highest biofilm inhibition upto 83.68 ± 0.09 % against A.
baumannii.
Biofilms of P.
aeruginosa, E.
coli, and S.
aureus were inhibited up to 18.93 ± 1.94 %, 22.33 ± 0.56 %, and 30.70 ± 1.33 %, respectively.
Scanning electron microscopy (SEM) and atomic force microscopy (AFM) confirmed unregulated cellular efflux through pore formation leading to cell death.
Potent antileishmanial activity of Au core Ag shell NPs ( MIC = 32 µg/mL) was confirmed by MTT assay.
Further SEM micrographs showed pronounced deformity in the spindle shaped cellular morphology changing to spherical.
This is the first report of synthesis, characterization, antibiofilm, and antileishmanial activity of Au core Ag shell NPs synthesized by D.
bulbifera.
American Psychological Association (APA)
Ghosh, Sougata& Jagtap, Soham& More, Piyush& Shete, Usha J.& Maheshwari, Neeraj O.& Rao, Shilpa J.…[et al.]. 2015. Dioscorea bulbifera Mediated Synthesis of Novel AucoreAgshell Nanoparticles with Potent Antibiofilm and Antileishmanial Activity. Journal of Nanomaterials،Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1069127
Modern Language Association (MLA)
Ghosh, Sougata…[et al.]. Dioscorea bulbifera Mediated Synthesis of Novel AucoreAgshell Nanoparticles with Potent Antibiofilm and Antileishmanial Activity. Journal of Nanomaterials No. 2015 (2015), pp.1-12.
https://search.emarefa.net/detail/BIM-1069127
American Medical Association (AMA)
Ghosh, Sougata& Jagtap, Soham& More, Piyush& Shete, Usha J.& Maheshwari, Neeraj O.& Rao, Shilpa J.…[et al.]. Dioscorea bulbifera Mediated Synthesis of Novel AucoreAgshell Nanoparticles with Potent Antibiofilm and Antileishmanial Activity. Journal of Nanomaterials. 2015. Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1069127
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1069127