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Supramolecular Encapsulation of Vitamin B6 by Macrocyclic Nanocontainer Cucurbit[7]uril
Joint Authors
Zhang, Qing-Wen
Wang, Ruibing
Li, Wanying
Li, Shengke
Wyman, Ian W.
Macartney, Donal H.
Zheng, Ying
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-11-18
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
A pharmaceutically and biologically relevant molecule, pyridoxine hydrochloride (vitamin B6), was encapsulated inside the cavity of a molecular container, cucurbit[7]uril (CB[7]), in aqueous solution.
The CB[7] based “nanocapsule” of vitamin B6 has been investigated for the first time, via 1H NMR and UV-visible spectroscopic titrations (including Job’s plot) and ab initio molecular modeling.
The results have demonstrated that vitamin B6 forms stable host-guest complexes within CB[7] in 1 : 1 stoichiometry, with a binding affinity of (4.0±0.5)×103 M−1.
Such a nanocapsule could potentially find application in vitamin B6 formulation for the purpose of enhancing the stability, absorption, and delivery of this important vitamin.
American Psychological Association (APA)
Li, Wanying& Li, Shengke& Wyman, Ian W.& Macartney, Donal H.& Zhang, Qing-Wen& Zheng, Ying…[et al.]. 2015. Supramolecular Encapsulation of Vitamin B6 by Macrocyclic Nanocontainer Cucurbit[7]uril. Journal of Nanomaterials،Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1069138
Modern Language Association (MLA)
Li, Wanying…[et al.]. Supramolecular Encapsulation of Vitamin B6 by Macrocyclic Nanocontainer Cucurbit[7]uril. Journal of Nanomaterials No. 2015 (2015), pp.1-6.
https://search.emarefa.net/detail/BIM-1069138
American Medical Association (AMA)
Li, Wanying& Li, Shengke& Wyman, Ian W.& Macartney, Donal H.& Zhang, Qing-Wen& Zheng, Ying…[et al.]. Supramolecular Encapsulation of Vitamin B6 by Macrocyclic Nanocontainer Cucurbit[7]uril. Journal of Nanomaterials. 2015. Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1069138
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1069138