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Iterative Cellular Screening System for Nanoparticle Safety Testing
Joint Authors
Bahnemann, Detlef W.
Kasper, Cornelia
Sambale, F.
Stahl, F.
Scheper, T.
Rüdinger, Ferdinand
Seliktar, Dror
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-08-19
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Abstract EN
Nanoparticles have the potential to exhibit risks to human beings and to the environment; due to the wide applications of nanoproducts, extensive risk management must not be neglected.
Therefore, we have constructed a cell-based, iterative screening system to examine a variety of nanoproducts concerning their toxicity during development.
The sensitivity and application of various cell-based methods were discussed and proven by applying the screening to two different nanoparticles: zinc oxide and titanium dioxide nanoparticles.
They were used as benchmarks to set up our methods and to examine their effects on mammalian cell lines.
Different biological processes such as cell viability, gene expression of interleukin-8 and heat shock protein 70, as well as morphology changes were investigated.
Within our screening system, both nanoparticle suspensions and coatings can be tested.
Electric cell impedance measurements revealed to be a good method for online monitoring of cellular behavior.
The implementation of three-dimensional cell culture is essential to better mimic in vivo conditions.
In conclusion, our screening system is highly efficient, cost minimizing, and reduces the need for animal studies.
American Psychological Association (APA)
Sambale, F.& Stahl, F.& Rüdinger, Ferdinand& Seliktar, Dror& Kasper, Cornelia& Bahnemann, Detlef W.…[et al.]. 2015. Iterative Cellular Screening System for Nanoparticle Safety Testing. Journal of Nanomaterials،Vol. 2015, no. 2015, pp.1-16.
https://search.emarefa.net/detail/BIM-1069233
Modern Language Association (MLA)
Sambale, F.…[et al.]. Iterative Cellular Screening System for Nanoparticle Safety Testing. Journal of Nanomaterials No. 2015 (2015), pp.1-16.
https://search.emarefa.net/detail/BIM-1069233
American Medical Association (AMA)
Sambale, F.& Stahl, F.& Rüdinger, Ferdinand& Seliktar, Dror& Kasper, Cornelia& Bahnemann, Detlef W.…[et al.]. Iterative Cellular Screening System for Nanoparticle Safety Testing. Journal of Nanomaterials. 2015. Vol. 2015, no. 2015, pp.1-16.
https://search.emarefa.net/detail/BIM-1069233
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1069233