Development of Polymeric Nanoparticles of Garcinia mangostana Xanthones in Eudragit RL100RS100 for Anti-Colon Cancer Drug Delivery
Joint Authors
Abdul Majid, A. M. S.
Ismail, Zhari
Aisha, Abdalrahim F. A.
Alrokayan, Salman A.
Abu-Salah, Khalid M.
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-11-29
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Xanthones are a group of oxygenated heterocyclic compounds with anticancer properties, but poor aqueous solubility and low oral bioavailability hinder their therapeutic application.
This study sought to prepare a xanthones extract (81% α-mangostin and 16% γ-mangostin) in polymeric nanoparticles and to investigate its intracellular delivery and cytotoxicity toward colon cancer cells.
The nanoparticles were prepared in Eudragit RL100 and Eudragit RS100 by the nanoprecipitation method at drug loading and entrapment efficiency of 20% and >95%, respectively.
Freeze-drying of bulk nanoparticle solutions, using glucose or sucrose as cryoprotectants, allowed the collection of nanoparticles at >95% yield.
Solubility of the xanthones extract was improved from 0.1 µg/mL to 1250 µg/mL.
Transmission electron microscopy (TEM) and dynamic light scattering (DLS) of the freeze-dried final formulation showed the presence of cationic round nanoparticles, with particle size in the range of 32–130 nm.
Scanning electron microscopy (SEM) showed the presence of nanospheres, and Fourier transform infrared (FTIR) spectroscopy indicated intermolecular interaction of xanthones with Eudragit polymers.
Cellular uptake of nanoparticles was mediated via endocytosis and indicated intracellular delivery of xanthones associated with potent cytotoxicity (median inhibitory concentration 26.3 ± 0.22 µg/mL).
Presented results suggest that cationic nanoparticles of xanthones may provide a novel oral drug delivery system for chemoprevention or treatment of intestinal and colon tumors.
American Psychological Association (APA)
Aisha, Abdalrahim F. A.& Abdul Majid, A. M. S.& Ismail, Zhari& Alrokayan, Salman A.& Abu-Salah, Khalid M.. 2015. Development of Polymeric Nanoparticles of Garcinia mangostana Xanthones in Eudragit RL100RS100 for Anti-Colon Cancer Drug Delivery. Journal of Nanomaterials،Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1069244
Modern Language Association (MLA)
Aisha, Abdalrahim F. A.…[et al.]. Development of Polymeric Nanoparticles of Garcinia mangostana Xanthones in Eudragit RL100RS100 for Anti-Colon Cancer Drug Delivery. Journal of Nanomaterials No. 2015 (2015), pp.1-12.
https://search.emarefa.net/detail/BIM-1069244
American Medical Association (AMA)
Aisha, Abdalrahim F. A.& Abdul Majid, A. M. S.& Ismail, Zhari& Alrokayan, Salman A.& Abu-Salah, Khalid M.. Development of Polymeric Nanoparticles of Garcinia mangostana Xanthones in Eudragit RL100RS100 for Anti-Colon Cancer Drug Delivery. Journal of Nanomaterials. 2015. Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1069244
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1069244