Antibacterial Membrane with a Bone-Like Structure for Guided Bone Regeneration
Joint Authors
Zhang, YuYuan
Mao, WeiJia
Wang, Jian
Mei, May Lei
Chu, Chun Hung
Xia, Rong
Zhang, Zhi-Hong
Li, Quanli
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-09-21
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
An antibacterial membrane with a bone-like structure was developed for guided bone regeneration (GBR) by mineralising acellular bovine pericardium (ABP) and loading it with the antibiotic minocycline.
The bovine pericardium (BP) membrane was processed using physical and chemical methods to remove the cellular components and obtain ABP membranes.
Then, the ABP membranes were biomimetically mineralised using a calcium phosphate-loaded agarose hydrogel system aided by electrophoresis.
Minocycline was adsorbed to the mineralised ABP membrane, and the release profile in vitro was studied.
The membranes were characterised through scanning electron microscopy, diffuse reflectance-Fourier transform infrared spectroscopy, and X-ray diffraction.
Results showed that the ABP membrane had an asymmetric structure with a layer of densely arranged and irregularly aligned collagen fibrils.
Collagen fibrils were calcified with the formation of intrafibrillar and interfibrillar hydroxyapatites similar to the bone structure.
Minocycline was incorporated into the mineralised collagen membrane and could be released in vitro.
This process endowed the membrane with an antibacterial property.
This novel composite membrane offers promising applications in bioactive GBR.
American Psychological Association (APA)
Zhang, YuYuan& Mao, WeiJia& Wang, Jian& Li, Quanli& Mei, May Lei& Chu, Chun Hung…[et al.]. 2015. Antibacterial Membrane with a Bone-Like Structure for Guided Bone Regeneration. Journal of Nanomaterials،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1069304
Modern Language Association (MLA)
Zhang, YuYuan…[et al.]. Antibacterial Membrane with a Bone-Like Structure for Guided Bone Regeneration. Journal of Nanomaterials No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1069304
American Medical Association (AMA)
Zhang, YuYuan& Mao, WeiJia& Wang, Jian& Li, Quanli& Mei, May Lei& Chu, Chun Hung…[et al.]. Antibacterial Membrane with a Bone-Like Structure for Guided Bone Regeneration. Journal of Nanomaterials. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1069304
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1069304