Antibacterial Activity and Cytocompatibility of PLGACuO Hybrid Nanofiber Scaffolds Prepared by Electrospinning

Abstract EN

The PLGA/CuO hybrid nanofibers scaffolds were prepared via electrospinning technique.

The presence of CuO in the PLGA scaffolds was confirmed by transmission electron microscope (TEM) and X-ray photoelectron spectroscopy (XPS).

The scaffolds were subjected to various antibacterial and cytobiocompatibility tests.

The results not only showed excellent adhesion, proliferation, and viability (live/dead staining) for fibroblastic cells but also revealed that PLGA/CuO hybrid nanofiber scaffolds inhibited both Gram-positive and Gram-negative bacterial growth.

The mechanism of the antibacterial activity was concluded to be based on the CuO nanoparticles and Cu++ ions release.

It is, therefore, evaluated that PLGA/CuO hybrid nanofiber scaffolds can be a useful candidate for wound dressing.