Investigations into the Biocompatibility of Nanohydroxyapatite Coated Magnetic Nanoparticles under Magnetic Situation
Joint Authors
Zhou, Gang
Hou, Yongzhao
Wei, Yan
Li, Qing
Wang, Tong
Deng, Xuliang
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-05-19
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Regenerative medicine consisting of cells and materials offers a new approach for repairing and regenerating the organs and tissues.
More and more researches focused on the magnetic nanobiomaterials due to its superior advantages to traditional materials.
However, the toxicity of nanosized magnetic particles cannot be ignored, especially under the magnetic situation.
This study aims to study the biocompatibility of nanohydroxyapatite (n-HA-) coated magnetic nanoparticles under the magnetic situation.
n-HA-coated magnetic nanoparticles were fabricated through an ultrasound-assisted coprecipitation method.
Subsequently, these materials were analyzed by transmission electron microscope (TEM) and X-ray diffraction (XRD) and then were cultured with mesenchyme stem cells derived from human bone marrow (hMSC-BM).
In vitro experiment proved the satisfactory biocompatibility of n-HA-coated magnetic nanoparticles.
These important factors (ALP, OCN, and OPN) influence the osteogenic differentiation of hMSC-BM.
It was found that the hMSC-BM with combination of n-HA/Fe3O4 and magnetic stimulation presented higher degree of osteoblast-related markers than that in each alone.
This research demonstrated that a novel nanohydroxyapatite coated magnetic nanoparticle is safe under the magnetic situation.
Therefore, these n-HA-coated magnetic nanoparticles are promising biomagnetic materials for future applications.
American Psychological Association (APA)
Li, Qing& Zhou, Gang& Wang, Tong& Hou, Yongzhao& Deng, Xuliang& Wei, Yan. 2015. Investigations into the Biocompatibility of Nanohydroxyapatite Coated Magnetic Nanoparticles under Magnetic Situation. Journal of Nanomaterials،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1069359
Modern Language Association (MLA)
Li, Qing…[et al.]. Investigations into the Biocompatibility of Nanohydroxyapatite Coated Magnetic Nanoparticles under Magnetic Situation. Journal of Nanomaterials No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1069359
American Medical Association (AMA)
Li, Qing& Zhou, Gang& Wang, Tong& Hou, Yongzhao& Deng, Xuliang& Wei, Yan. Investigations into the Biocompatibility of Nanohydroxyapatite Coated Magnetic Nanoparticles under Magnetic Situation. Journal of Nanomaterials. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1069359
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1069359