Functionalization of Hollow Mesoporous Silica Nanoparticles for Improved 5-FU Loading
Joint Authors
Kong, L. X.
She, Xiaodong
Chen, Lijue
Li, Chengpeng
He, Canzhong
He, Li
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-03-16
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Hollow mesoporous silica nanoparticles were successfully fabricated and functionalized with appropriate silanes.
After modifications, amine, carboxyl, cyano, and methyl groups were grafted onto the nanoparticles and all functionalized hollow mesoporous silica nanoparticles maintained a spherical and hollow structure with a mean diameter of ~120 nm and a shell thickness of ~10 nm.
The loading capacity of the hollow mesoporous silica nanoaprticles to the anticancer drug, 5-fluorouracil, can be controlled via precise functionalization.
The presence of amine groups on the surface of nanoparticles resulted in the highest loading capacity of 28.89%, due to the amine functionalized nanoparticles having a similar hydrophilicity but reverse charge to the drug.
In addition, the change in pH leads to the variation of the intensity of electrostatic force between nanoparticles and the drug, which finally affects the loading capacity of amine functionalized hollow mesoporous silica nanoparticles to some extent.
Higher drug loading was observed at pH of 7.4 and 8.5 as 5-fluorouracil becomes more deprotonated in alkaline conditions.
The improved drug loading capacity by amine functionalized hollow mesoporous silica nanoparticles has demonstrated that they can become potential intracellular 5-fluorouracil delivery vehicles for cancers.
American Psychological Association (APA)
She, Xiaodong& Chen, Lijue& Li, Chengpeng& He, Canzhong& He, Li& Kong, L. X.. 2015. Functionalization of Hollow Mesoporous Silica Nanoparticles for Improved 5-FU Loading. Journal of Nanomaterials،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1069392
Modern Language Association (MLA)
She, Xiaodong…[et al.]. Functionalization of Hollow Mesoporous Silica Nanoparticles for Improved 5-FU Loading. Journal of Nanomaterials No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1069392
American Medical Association (AMA)
She, Xiaodong& Chen, Lijue& Li, Chengpeng& He, Canzhong& He, Li& Kong, L. X.. Functionalization of Hollow Mesoporous Silica Nanoparticles for Improved 5-FU Loading. Journal of Nanomaterials. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1069392
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1069392