Preparation and Characterization of Paclitaxel Loaded SFPLLA-PEG-PLLA Nanoparticles via Solution-Enhanced Dispersion by Supercritical CO2
Joint Authors
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-10-25
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Paclitaxel loaded silk fibroin/PLLA-PEG-PLLA (PTX-SF/PLLA-PEG-PLLA) nanoparticles with a mean particle size of about 651 nm were fabricated successfully by the SEDS process.
Fourier transform infrared (FTIR) spectroscopy analysis indicated that the PTX was encapsulated by SF/PLLA-PEG-PLLA nanoparticles.
X-ray powder diffraction (XRPD) analysis supported the results of FTIR analysis and also suggested that the crystalline state of PTX was decreased obviously.
Furthermore, the UV-Vis/HPLC analysis showed that drug load (DL) and encapsulation efficiency (EE) were 18.1% and 90.2%, respectively.
The in vitro drug release experiment suggested that the PTX-SF/PLLA-PEG-PLLA nanoparticles exhibited a sustained release and only 16.1% and 24.5% of paclitaxel were released at pH 7.4 and 6.0, respectively, in one week.
The PTX-SF/PLLA-PEG-PLLA nanoparticles drug delivery system with pH-dependent release property has potential application in the field of tumor therapy.
American Psychological Association (APA)
Zhao, Zheng& Li, Yi& Zhang, Yu. 2015. Preparation and Characterization of Paclitaxel Loaded SFPLLA-PEG-PLLA Nanoparticles via Solution-Enhanced Dispersion by Supercritical CO2. Journal of Nanomaterials،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1069428
Modern Language Association (MLA)
Zhao, Zheng…[et al.]. Preparation and Characterization of Paclitaxel Loaded SFPLLA-PEG-PLLA Nanoparticles via Solution-Enhanced Dispersion by Supercritical CO2. Journal of Nanomaterials No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1069428
American Medical Association (AMA)
Zhao, Zheng& Li, Yi& Zhang, Yu. Preparation and Characterization of Paclitaxel Loaded SFPLLA-PEG-PLLA Nanoparticles via Solution-Enhanced Dispersion by Supercritical CO2. Journal of Nanomaterials. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1069428
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1069428