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Elaboration of Nanoparticles Containing Indomethacin: Argan Oil for Transdermal Local and Cosmetic Application
Joint Authors
Badri, Waisudin
Miladi, Karim
Eddabra, Rkia
Fessi, Hatem
Elaissari, Abdelhamid
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-03-18
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The objective of this work is the preparation of nanocapsules which are intended for the treatment of rheumatoid arthritis (RA).
We use Argan oil as vehicle of hydrophobic drugs such as indomethacin.
Nanoprecipitation technique was used like a method for preparation of nanocapsules, where polycaprolactone, acetone, and Argan oil are used as polymer, solvent, and carrier, respectively.
Primarily, investigation of Argan oil amount addition was performed; then systematic study to optimize the formulation was done.
Nanocapsules containing indomethacin (loaded nanocapsules) and others without indomethacin (blank nanocapsules) were characterized by studying particles size, zeta potential, and encapsulation efficiency.
It is shown that particle size ranged between 290 nm and 350 nm.
The zeta potential values were negative (from −40 up to −50 mV) while encapsulation efficiency ranged between 65 and 75%.
American Psychological Association (APA)
Badri, Waisudin& Miladi, Karim& Eddabra, Rkia& Fessi, Hatem& Elaissari, Abdelhamid. 2015. Elaboration of Nanoparticles Containing Indomethacin: Argan Oil for Transdermal Local and Cosmetic Application. Journal of Nanomaterials،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1069447
Modern Language Association (MLA)
Badri, Waisudin…[et al.]. Elaboration of Nanoparticles Containing Indomethacin: Argan Oil for Transdermal Local and Cosmetic Application. Journal of Nanomaterials No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1069447
American Medical Association (AMA)
Badri, Waisudin& Miladi, Karim& Eddabra, Rkia& Fessi, Hatem& Elaissari, Abdelhamid. Elaboration of Nanoparticles Containing Indomethacin: Argan Oil for Transdermal Local and Cosmetic Application. Journal of Nanomaterials. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1069447
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1069447