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Cyclic Strain Enhances Cellular Uptake of Nanoparticles
Joint Authors
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-08-17
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Nanoparticles (NPs) have gained increasing interest in recent years due to their potential use as drug carrier, imaging, and diagnostic agents in pharmaceutical and biomedical applications.
While many cells in vivo experience mechanical forces, little is known about the correlation of the mechanical stimulation and the internalization of NPs into cells.
This paper investigates the effects of applied cyclic strain on NP uptake by cells.
Bovine aortic endothelial cells (BAECs) were cultured on collagen-coated culture plates and placed under cyclic equal-axial strains.
NPs of sizes ranging from 50 to 200 nm were loaded at a concentration of 0.02 mg/mL and cyclic strains from 5 to 15% were applied to the cells for one hour.
The cyclic strain results in a significant enhancement in NP uptake, which increases almost linearly with strain level.
The enhanced uptake also depends on size of the NPs with the highest uptake observed on 100 nm NP.
The effect of enhanced NP uptake lasts around 13 hours after cyclic stretch.
Such in vitro cell stretch systems mimic physiological conditions of the endothelial cells in vivo and could potentially serve as a biomimetic platform for drug therapeutic evaluation.
American Psychological Association (APA)
Hu, Jia& Liu, Yaling. 2015. Cyclic Strain Enhances Cellular Uptake of Nanoparticles. Journal of Nanomaterials،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1069464
Modern Language Association (MLA)
Hu, Jia& Liu, Yaling. Cyclic Strain Enhances Cellular Uptake of Nanoparticles. Journal of Nanomaterials No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1069464
American Medical Association (AMA)
Hu, Jia& Liu, Yaling. Cyclic Strain Enhances Cellular Uptake of Nanoparticles. Journal of Nanomaterials. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1069464
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1069464