Plasma Fatty Acids in Zambian Adults with HIVAIDS: Relation to Dietary Intake and Cardiovascular Risk Factors
Joint Authors
Tsai, Michael Y.
Blevins, Meridith
Chi, Benjamin H.
Kiage, James N.
Musonda, Patrick
Bosire, Claire N.
Kabagambe, Edmond K.
Nyirenda, Christopher K.
Koethe, John R.
Heimburger, Douglas C.
Source
Journal of Nutrition and Metabolism
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-05-26
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Objective.
To determine whether 24 hr dietary recalls (DR) are a good measure of polyunsaturated fatty acid (PUFA) intake when compared to plasma levels, and whether plasma PUFA is associated with markers of HIV/AIDS progression and cardiovascular disease (CVD) risk.
Methods.
In a cross-sectional study among 210 antiretroviral therapy-naïve HIV-infected adults from Lusaka, Zambia, we collected data on medical history and dietary intake using 24 hr DR.
We measured fatty acids and markers of AIDS progression and CVD risk in fasting plasma collected at baseline.
Results.
PUFA intakes showed modest correlations with corresponding plasma levels; Spearman correlations were 0.36 (p<0.01) for eicosapentaenoic acid and 0.21 (p=0.005) for docosahexaenoic acid.
While there were no significant associations (p>0.05) between total plasma PUFA and C-reactive protein (CRP) or lipid levels, plasma arachidonic acid was inversely associated with CRP and triglycerides and positively associated with HDL-C, CD4+ T-cell count, and plasma albumin (p<0.05).
Plasma saturated fatty acids (SFA) were positively associated with CRP (β = 0.24; 95% CI: 0.08 to 0.40, p=0.003) and triglycerides (β = 0.08; 95% CI: 0.03 to 0.12, p<0.01).
Conclusions.
Our data suggest that a single DR is inadequate for assessing PUFA intake and that plasma arachidonic acid levels may modulate HIV/AIDS progression and CVD risk.
American Psychological Association (APA)
Nyirenda, Christopher K.& Kabagambe, Edmond K.& Koethe, John R.& Kiage, James N.& Chi, Benjamin H.& Musonda, Patrick…[et al.]. 2015. Plasma Fatty Acids in Zambian Adults with HIVAIDS: Relation to Dietary Intake and Cardiovascular Risk Factors. Journal of Nutrition and Metabolism،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1069517
Modern Language Association (MLA)
Nyirenda, Christopher K.…[et al.]. Plasma Fatty Acids in Zambian Adults with HIVAIDS: Relation to Dietary Intake and Cardiovascular Risk Factors. Journal of Nutrition and Metabolism No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1069517
American Medical Association (AMA)
Nyirenda, Christopher K.& Kabagambe, Edmond K.& Koethe, John R.& Kiage, James N.& Chi, Benjamin H.& Musonda, Patrick…[et al.]. Plasma Fatty Acids in Zambian Adults with HIVAIDS: Relation to Dietary Intake and Cardiovascular Risk Factors. Journal of Nutrition and Metabolism. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1069517
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1069517