Dissecting the Potential Interplay of DEK Functions in Inflammation and Cancer
Joint Authors
Pease, Nicholas A.
Wise-Draper, Trisha
Privette Vinnedge, Lisa
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-09-06
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
There is a long-standing correlation between inflammation, inflammatory cell signaling pathways, and tumor formation.
Understanding the mechanisms behind inflammation-driven tumorigenesis is of great research and clinical importance.
Although not entirely understood, these mechanisms include a complex interaction between the immune system and the damaged epithelium that is mediated by an array of molecular signals of inflammation—including reactive oxygen species (ROS), cytokines, and NFκB signaling—that are also oncogenic.
Here, we discuss the association of the unique DEK protein with these processes.
Specifically, we address the role of DEK in chronic inflammation via viral infections and autoimmune diseases, the overexpression and oncogenic activity of DEK in cancers, and DEK-mediated regulation of NFκB signaling.
Combined, evidence suggests that DEK may play a complex, multidimensional role in chronic inflammation and subsequent tumorigenesis.
American Psychological Association (APA)
Pease, Nicholas A.& Wise-Draper, Trisha& Privette Vinnedge, Lisa. 2015. Dissecting the Potential Interplay of DEK Functions in Inflammation and Cancer. Journal of Oncology،Vol. 2015, no. 2015, pp.1-13.
https://search.emarefa.net/detail/BIM-1069559
Modern Language Association (MLA)
Pease, Nicholas A.…[et al.]. Dissecting the Potential Interplay of DEK Functions in Inflammation and Cancer. Journal of Oncology No. 2015 (2015), pp.1-13.
https://search.emarefa.net/detail/BIM-1069559
American Medical Association (AMA)
Pease, Nicholas A.& Wise-Draper, Trisha& Privette Vinnedge, Lisa. Dissecting the Potential Interplay of DEK Functions in Inflammation and Cancer. Journal of Oncology. 2015. Vol. 2015, no. 2015, pp.1-13.
https://search.emarefa.net/detail/BIM-1069559
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1069559