Evaluation of AgNORs in Oral Potentially Malignant Lesions
Joint Authors
Tomazelli, Karin Berria
Modolo, Filipe
Rivero, Elena Riet Correa
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-08-31
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Oral squamous cell carcinoma (OSCC) is usually preceded by detectable mucosal changes, as leukoplakias and erythroplakia.
Histologically, these lesions can range from hyperkeratosis and acanthosis to epithelial dysplasia and even OSCC.
The aim of this study was to investigate the proliferative activity, using AgNORs quantification proteins, in low- and high-risk oral epithelial dysplasia, OSCC, and nondysplastic epithelium (inflammatory fibrous hyperplasia).
The sample was divided into 4 groups: G1: 10 cases of inflammatory fibrous hyperplasia (IFH), G2: 11 cases of low-risk epithelial dysplasia (LD), G3: 10 cases of high-risk epithelial dysplasia (HD), and G4: 11 cases of OSCC.
The quantitative analysis was performed using an image processing software in photomicrographs at 1000x magnification.
The one-way ANOVA was used for comparison of the mean AgNORs counts between the study groups.
The mean AgNORs count was significantly higher P ≤ 0.01 in OSCC when compared to IFH and the LD; however, it was not statistically different from HD.
The mean number of LD was significantly lower than the HD and OSCC, with no difference related to IFH.
AgNORs quantification can be an important and cheap method to help in the determination of the degree of epithelial dysplasia and, consequently, in the analysis of their potential for malignant transformation.
American Psychological Association (APA)
Tomazelli, Karin Berria& Modolo, Filipe& Rivero, Elena Riet Correa. 2015. Evaluation of AgNORs in Oral Potentially Malignant Lesions. Journal of Oncology،Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1069564
Modern Language Association (MLA)
Tomazelli, Karin Berria…[et al.]. Evaluation of AgNORs in Oral Potentially Malignant Lesions. Journal of Oncology No. 2015 (2015), pp.1-6.
https://search.emarefa.net/detail/BIM-1069564
American Medical Association (AMA)
Tomazelli, Karin Berria& Modolo, Filipe& Rivero, Elena Riet Correa. Evaluation of AgNORs in Oral Potentially Malignant Lesions. Journal of Oncology. 2015. Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1069564
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1069564