Small Cell Carcinoma of the Gallbladder: Case Report and Comprehensive Analysis of Published Cases
Joint Authors
Carrera, Carolyn
Kunk, Paul
Rahma, Osama
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-12-28
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Background.
Gallbladder small cell carcinoma is a rare and highly aggressive malignancy with no established standard of care treatment.
We described here a case report of small cell gallbladder cancer and we then performed a comprehensive review of 72 case reports of this disease.
Methods.
Published case reports of small cell carcinoma of the gallbladder between 1983 and 2014 were reviewed.
Treatment modalities and survival were analyzed for metastatic and localized disease.
Results.
Median overall survival for all patients was 13 months.
Metastatic disease was identified in 72% of cases.
Treatment of metastatic disease with chemotherapy showed a significant survival benefit (p<0.001) compared to no chemotherapy, and the use of platinum doublet with etoposide showed a nonsignificant 4-month improvement in survival compared to other chemotherapy regimens (p=0.13).
Adjuvant therapy did not demonstrate an improvement of median overall survival in local disease (p=0.78).
Conclusion.
Given the limited available data, systemic therapy with platinum and etoposide should be considered for patients with metastatic small cell carcinoma of the gallbladder.
Adjuvant chemoradiation or chemotherapy for treatment of local disease warrants further investigation.
American Psychological Association (APA)
Carrera, Carolyn& Kunk, Paul& Rahma, Osama. 2015. Small Cell Carcinoma of the Gallbladder: Case Report and Comprehensive Analysis of Published Cases. Journal of Oncology،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1069567
Modern Language Association (MLA)
Carrera, Carolyn…[et al.]. Small Cell Carcinoma of the Gallbladder: Case Report and Comprehensive Analysis of Published Cases. Journal of Oncology No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1069567
American Medical Association (AMA)
Carrera, Carolyn& Kunk, Paul& Rahma, Osama. Small Cell Carcinoma of the Gallbladder: Case Report and Comprehensive Analysis of Published Cases. Journal of Oncology. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1069567
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1069567