Prognostic Impact of Hypoxia-Inducible miRNA-210 in Patients with Lung Adenocarcinoma
Joint Authors
Osugi, Jun
Kimura, Yuka
Owada, Yuki
Inoue, Takuya
Watanabe, Yuzuru
Yamaura, Takumi
Fukuhara, Mitsuro
Muto, Satoshi
Okabe, Naoyuki
Matsumura, Yuki
Hasegawa, Takeo
Yonechi, Athushi
Hoshino, Mika
Higuchi, Mitsunori
Shio, Yutaka
Suzuki, Hiroyuki
Gotoh, Mitsukazu
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-02-05
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Objective.
The aim of this study was to investigate the prognostic value of MicroRNA-210 (miR-210) expression in patients with non-small-cell lung cancer (NSCLC).
Methods.
We examined the miR-210 expression of samples of 80 patients, who underwent surgical resection at Fukushima Medical University from 2004 to 2007, by using quantitative RT-PCR.
The relationship between miR-210 expression and clinicopathological factors as well as histological subtype was statistically analyzed.
Results.
miR-210 expression showed an inverse correlation with disease-free and overall survival in patients with NSCLC.
Significant correlations were found between miR-210 expression and lymph node metastasis, late disease stages, and poor prognosis in patients with adenocarcinoma.
Multivariate Cox analysis indicated that miR-210 expression was an independent prognostic factor for disease-free survival in patients with adenocarcinoma.
Conclusions.
We showed that miR-210 may be a prognostic biomarker for patients with NSCLC, especially for those with lung adenocarcinoma.
American Psychological Association (APA)
Osugi, Jun& Kimura, Yuka& Owada, Yuki& Inoue, Takuya& Watanabe, Yuzuru& Yamaura, Takumi…[et al.]. 2015. Prognostic Impact of Hypoxia-Inducible miRNA-210 in Patients with Lung Adenocarcinoma. Journal of Oncology،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1069568
Modern Language Association (MLA)
Osugi, Jun…[et al.]. Prognostic Impact of Hypoxia-Inducible miRNA-210 in Patients with Lung Adenocarcinoma. Journal of Oncology No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1069568
American Medical Association (AMA)
Osugi, Jun& Kimura, Yuka& Owada, Yuki& Inoue, Takuya& Watanabe, Yuzuru& Yamaura, Takumi…[et al.]. Prognostic Impact of Hypoxia-Inducible miRNA-210 in Patients with Lung Adenocarcinoma. Journal of Oncology. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1069568
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1069568