Comparison of Enoxaparin and Warfarin for Secondary Prevention of Cancer-Associated Stroke
Joint Authors
Jang, Hyemin
Lee, Jung Jae
Lee, Mi Ji
Ryoo, Sookyung
Yoon, Chang Hyo
Kim, Gyeong-Moon
Chung, Chin-Sang
Lee, Kwang Ho
Bang, Oh Young
Kim, Suk Jae
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-05-07
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Background.
The aim of this study was to determine which anticoagulant is superior for secondary prevention of cancer-associated stroke, using changes in D-dimer levels as a biomarker for recurrent thromboembolic events.
Methods.
We conducted a retrospective, single center observational study including patients with cancer-associated stroke who were treated with either enoxaparin or warfarin.
Blood samples for measuring the initial and follow-up D-dimer levels were collected at admission and a median of 8 days after admission, respectively.
Multiple logistic regression analysis was conducted to evaluate the factors that influenced D-dimer levels after treatment.
Results.
Although the initial D-dimer levels did not differ between the two groups, the follow-up levels were dramatically decreased in patients treated with enoxaparin, while they did not change with use of warfarin (3.88 μg/mL versus 17.42 μg/mL, p = 0.026 ).
On multiple logistic regression analysis, use of warfarin (OR 12.95; p = 0.001 ) and the presence of systemic metastasis (OR 18.73; p = 0.017 ) were independently associated with elevated D-dimer levels (≥10 μg/mL) after treatment.
Conclusion.
In cancer-associated stroke patients, treatment with enoxaparin may be more effective than treatment with warfarin for lowering the D-dimer levels.
Future prospective studies are warranted to show that enoxaparin is better than warfarin for secondary prevention in cancer-associated stroke.
American Psychological Association (APA)
Jang, Hyemin& Lee, Jung Jae& Lee, Mi Ji& Ryoo, Sookyung& Yoon, Chang Hyo& Kim, Gyeong-Moon…[et al.]. 2015. Comparison of Enoxaparin and Warfarin for Secondary Prevention of Cancer-Associated Stroke. Journal of Oncology،Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1069572
Modern Language Association (MLA)
Jang, Hyemin…[et al.]. Comparison of Enoxaparin and Warfarin for Secondary Prevention of Cancer-Associated Stroke. Journal of Oncology No. 2015 (2015), pp.1-6.
https://search.emarefa.net/detail/BIM-1069572
American Medical Association (AMA)
Jang, Hyemin& Lee, Jung Jae& Lee, Mi Ji& Ryoo, Sookyung& Yoon, Chang Hyo& Kim, Gyeong-Moon…[et al.]. Comparison of Enoxaparin and Warfarin for Secondary Prevention of Cancer-Associated Stroke. Journal of Oncology. 2015. Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1069572
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1069572