Epithelial to Mesenchymal Transition in a Clinical Perspective
Joint Authors
Pasquier, Jennifer
Abu-Kaoud, Nadine
Al Thani, Haya
Tabrizi, Arash Rafii
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-09-06
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Tumor growth and metastatic dissemination rely on cellular plasticity.
Among the different phenotypes acquired by cancer cells, epithelial to mesenchymal transition (EMT) has been extensively illustrated.
Indeed, this transition allows an epithelial polarized cell to acquire a more mesenchymal phenotype with increased mobility and invasiveness.
The role of EMT is quite clear during developmental stage.
In the neoplastic context in many tumors EMT has been associated with a more aggressive tumor phenotype including local invasion and distant metastasis.
EMT allows the cell to invade surrounding tissues and survive in the general circulation and through a stem cell phenotype grown in the host organ.
The molecular pathways underlying EMT have also been clearly defined and their description is beyond the scope of this review.
Here we will summarize and analyze the attempts made to block EMT in the therapeutic context.
Indeed, till today, most of the studies are made in animal models.
Few clinical trials are ongoing with no obvious benefits of EMT inhibitors yet.
We point out the limitations of EMT targeting such tumor heterogeneity or the dynamics of EMT during disease progression.
American Psychological Association (APA)
Pasquier, Jennifer& Abu-Kaoud, Nadine& Al Thani, Haya& Tabrizi, Arash Rafii. 2015. Epithelial to Mesenchymal Transition in a Clinical Perspective. Journal of Oncology،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1069587
Modern Language Association (MLA)
Pasquier, Jennifer…[et al.]. Epithelial to Mesenchymal Transition in a Clinical Perspective. Journal of Oncology No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1069587
American Medical Association (AMA)
Pasquier, Jennifer& Abu-Kaoud, Nadine& Al Thani, Haya& Tabrizi, Arash Rafii. Epithelial to Mesenchymal Transition in a Clinical Perspective. Journal of Oncology. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1069587
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1069587