The Prevalence of Cardiac Risk Factors in Men with Localized Prostate Cancer Undergoing Androgen Deprivation Therapy in British Columbia, Canada
Joint Authors
Pickles, T.
Davis, Margot K.
Rajala, Jennifer L.
Tyldesley, Scott
Virani, Sean A.
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-08-02
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Background.
While androgen deprivation therapy (ADT) reduces the risk of prostate cancer-specific mortality in high-risk localized prostate cancer, it adversely affects cardiovascular (CV) risk factor profiles in treated men.
Methods.
We retrospectively reviewed the charts of 100 consecutive men with intermediate- or high-risk localized prostate cancer referred to the British Columbia Cancer Agency for ADT.
Data on CV risk factors and disease were collected and Framingham risk scores were calculated.
Results.
The median age of the study cohort was 73 years.
Established cardiovascular disease was present in 25% of patients.
Among patients without established CV disease, calculated Framingham risk was high in 65%, intermediate in 33%, and low in 1%.
Baseline hypertension was present in 58% of patients, dyslipidemia in 51%, and diabetes or impaired glucose tolerance in 24%.
Hypertension was more prevalent in the study cohort than in an age- and sex-matched population sample (OR 1.74, P = 0.006 ); diabetes had a similar prevalence (OR 0.93, P = 0.8 ).
Conclusions.
Patients receiving ADT have a high prevalence of cardiovascular disease and risk factors and are more likely to be hypertensive than population controls.
Low rates of CV risk screening suggest opportunities for improved primary and secondary prevention of CV disease in this population.
American Psychological Association (APA)
Davis, Margot K.& Rajala, Jennifer L.& Tyldesley, Scott& Pickles, T.& Virani, Sean A.. 2015. The Prevalence of Cardiac Risk Factors in Men with Localized Prostate Cancer Undergoing Androgen Deprivation Therapy in British Columbia, Canada. Journal of Oncology،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1069589
Modern Language Association (MLA)
Davis, Margot K.…[et al.]. The Prevalence of Cardiac Risk Factors in Men with Localized Prostate Cancer Undergoing Androgen Deprivation Therapy in British Columbia, Canada. Journal of Oncology No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1069589
American Medical Association (AMA)
Davis, Margot K.& Rajala, Jennifer L.& Tyldesley, Scott& Pickles, T.& Virani, Sean A.. The Prevalence of Cardiac Risk Factors in Men with Localized Prostate Cancer Undergoing Androgen Deprivation Therapy in British Columbia, Canada. Journal of Oncology. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1069589
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1069589