Evolving Concepts: Immunity in Oncology from Targets to Treatments
Joint Authors
Khan, Hina
Gucalp, Rasim
Shapira, Iuliana
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-04-28
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Cancer is associated with global immune suppression of the host.
Malignancy-induced immune suppressive effect can be circumvented by blocking the immune checkpoint and tip the immune balance in favor of immune stimulation and unleash cytotoxic effects on cancer cells.
Human antibodies directed against immune checkpoint proteins: cytotoxic T lymphocytes antigen-4 (CTLA-4) and programmed death-1 (PD-1), programmed death-ligand 1 (PD-L1), have shown therapeutic efficacy in advanced melanoma and non-small-cell lung cancer and other malignancies.
Immune check point blockade antibodies lead to diminished tolerance to self and enhanced immune ability to recognize and eliminate cancer cells.
As a class these agents have immune-related adverse events due to decreased ability of effector immune cells to discriminate between self and non-self.
Seventy percent of patients participating in clinical trials have experienced anticancer activities and varying degrees of immune mediated dose-limiting side effects.
American Psychological Association (APA)
Khan, Hina& Gucalp, Rasim& Shapira, Iuliana. 2015. Evolving Concepts: Immunity in Oncology from Targets to Treatments. Journal of Oncology،Vol. 2015, no. 2015, pp.1-15.
https://search.emarefa.net/detail/BIM-1069590
Modern Language Association (MLA)
Khan, Hina…[et al.]. Evolving Concepts: Immunity in Oncology from Targets to Treatments. Journal of Oncology No. 2015 (2015), pp.1-15.
https://search.emarefa.net/detail/BIM-1069590
American Medical Association (AMA)
Khan, Hina& Gucalp, Rasim& Shapira, Iuliana. Evolving Concepts: Immunity in Oncology from Targets to Treatments. Journal of Oncology. 2015. Vol. 2015, no. 2015, pp.1-15.
https://search.emarefa.net/detail/BIM-1069590
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1069590