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Genetic and Diet-Induced Obesity Increased Intestinal Tumorigenesis in the Double Mutant Mouse Model Multiple Intestinal Neoplasia X Obese via Disturbed Glucose Regulation and Inflammation
Joint Authors
Nygaard, Unni Cecilie
Ngo, Ha Thi
Hetland, Ragna Bogen
Steffensen, Inger-Lise
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-21, 21 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-08-10
Country of Publication
Egypt
No. of Pages
21
Main Subjects
Abstract EN
We have studied how spontaneous or carcinogen-induced intestinal tumorigenesis was affected by genetic or diet-induced obesity in C57BL/6J- A p c M i n / + X C57BL/6J- L e p o b / + mice.
Obesity was induced by the obese (ob) mutation in the lep gene coding for the hormone leptin, or by a 45% fat diet.
The effects of obesity were examined on spontaneous intestinal tumors caused by the multiple intestinal neoplasia (Min) mutation in the adenomatous polyposis coli (Apc) gene and on tumors induced by the dietary carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP).
F1 ob/ob (homozygous mutated) mice had increased body weight (bw) and number of spontaneous and PhIP-induced small intestinal tumors (in A p c M i n / + mice), versus ob/wt (heterozygous mutated) and wt/wt mice (homozygous wild-type).
A 45% fat diet exacerbated bw and spontaneous tumor numbers versus 10% fat, but not PhIP-induced tumors.
Except for bw, ob/wt and wt/wt were not significantly different.
The obesity caused hyperglucosemia and insulinemia in ob/ob mice.
A 45% fat diet further increased glucose, but not insulin.
Inflammation was seen as increased TNFα levels in ob/ob mice.
Thus the results implicate disturbed glucose regulation and inflammation as mechanisms involved in the association between obesity and intestinal tumorigenesis.
Ob/ob mice had shorter lifespan than ob/wt and wt/wt mice.
American Psychological Association (APA)
Ngo, Ha Thi& Hetland, Ragna Bogen& Nygaard, Unni Cecilie& Steffensen, Inger-Lise. 2015. Genetic and Diet-Induced Obesity Increased Intestinal Tumorigenesis in the Double Mutant Mouse Model Multiple Intestinal Neoplasia X Obese via Disturbed Glucose Regulation and Inflammation. Journal of Obesity،Vol. 2015, no. 2015, pp.1-21.
https://search.emarefa.net/detail/BIM-1069605
Modern Language Association (MLA)
Ngo, Ha Thi…[et al.]. Genetic and Diet-Induced Obesity Increased Intestinal Tumorigenesis in the Double Mutant Mouse Model Multiple Intestinal Neoplasia X Obese via Disturbed Glucose Regulation and Inflammation. Journal of Obesity No. 2015 (2015), pp.1-21.
https://search.emarefa.net/detail/BIM-1069605
American Medical Association (AMA)
Ngo, Ha Thi& Hetland, Ragna Bogen& Nygaard, Unni Cecilie& Steffensen, Inger-Lise. Genetic and Diet-Induced Obesity Increased Intestinal Tumorigenesis in the Double Mutant Mouse Model Multiple Intestinal Neoplasia X Obese via Disturbed Glucose Regulation and Inflammation. Journal of Obesity. 2015. Vol. 2015, no. 2015, pp.1-21.
https://search.emarefa.net/detail/BIM-1069605
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1069605