The Influence of Urinary Concentrations of Organophosphate Metabolites on the Relationship between BMI and Cardiometabolic Health Risk
Joint Authors
Kuk, Jennifer L.
Ranjbar, Mahsa
Rotondi, Michael A.
Ardern, C. I.
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-08-20
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
The objective was to determine whether detectable levels of OP metabolites influence the relationship between BMI and cardiometabolic health.
This cross-sectional study was conducted using 2227 adults from the 1999–2008 NHANES datasets.
Urinary concentrations of six dialkyl phosphate metabolites were dichotomized to above and below the detection limit.
Weighted multiple regression analysis was performed adjusting for confounding variables.
Independent of BMI, individuals with detectable metabolites had higher diastolic blood pressure (for dimethylphosphate, diethylphosphate, and diethyldithiophosphate; P<0.05), lower HDL (for diethyldithiophosphate; P=0.02), and higher triglyceride (for dimethyldithiophosphate; P=0.05) than those below detection.
Contrarily, those with detectable dimethylthiophosphate had better LDL, HDL, and total cholesterol, independent of BMI.
Individuals at a higher BMI range who had detectable diethylphosphate (interaction: P=0.03) and diethylthiophosphate (interaction: P=0.02) exhibited lower HDL, while little difference existed between OP metabolite detection statuses at lower BMIs.
Similarly, individuals with high BMIs and detectable diethylphosphate had higher triglyceride than those without detectable levels, while minimal differences between diethylphosphate detection statuses were observed at lower BMIs (interaction: P=0.02).
Thus, cardiometabolic health outcome differs depending on the specific OP metabolite being examined, with higher BMIs amplifying health risk.
American Psychological Association (APA)
Ranjbar, Mahsa& Rotondi, Michael A.& Ardern, C. I.& Kuk, Jennifer L.. 2015. The Influence of Urinary Concentrations of Organophosphate Metabolites on the Relationship between BMI and Cardiometabolic Health Risk. Journal of Obesity،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1069623
Modern Language Association (MLA)
Ranjbar, Mahsa…[et al.]. The Influence of Urinary Concentrations of Organophosphate Metabolites on the Relationship between BMI and Cardiometabolic Health Risk. Journal of Obesity No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1069623
American Medical Association (AMA)
Ranjbar, Mahsa& Rotondi, Michael A.& Ardern, C. I.& Kuk, Jennifer L.. The Influence of Urinary Concentrations of Organophosphate Metabolites on the Relationship between BMI and Cardiometabolic Health Risk. Journal of Obesity. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1069623
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1069623