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Protective Effects of Tamarillo (Cyphomandra betacea) Extract against High Fat Diet Induced Obesity in Sprague-Dawley Rats
Joint Authors
Rahmat, Asmah
Abdul Kadir, Noor Atiqah Aizan
Jaafar, Hawa Z. E.
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-06-11
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
This study aims to investigate the protective effect of Cyphomandra betacea in adult male Sprague-Dawley rats fed with high fat diet.
Rats were fed on either normal chow or high fat diet for 10 weeks for obesity induction phase and subsequently received C.
betacea extract at low dose (150 mg kg−1), medium dose (200 mg kg−1), or high dose (300 mg kg−1) or placebo via oral gavages for another 7 weeks for treatment phase.
Treatment of obese rats with C.
betacea extracts led to a significant decrease in total cholesterol and significant increase in HDL-C ( p < 0.05 ).
Also there was a trend of positive reduction in blood glucose, triglyceride, and LDL-C with positive reduction of body weight detected in medium and high dosage of C.
betacea extract.
Interestingly, C.
betacea treated rats showed positive improvement of superoxide dismutase (SOD) activity and glutathione peroxidase (GPx) activity along with a significant increase of total antioxidant status (TAS) ( p < 0.05 ).
Further, rats treated with C.
betacea show significantly lower in TNF-α and IL-6 activities ( p < 0.05 ).
This study demonstrates the potential use of Cyphomandra betacea extract for weight maintenance and complimentary therapy to suppress some obesity complication signs.
American Psychological Association (APA)
Abdul Kadir, Noor Atiqah Aizan& Rahmat, Asmah& Jaafar, Hawa Z. E.. 2015. Protective Effects of Tamarillo (Cyphomandra betacea) Extract against High Fat Diet Induced Obesity in Sprague-Dawley Rats. Journal of Obesity،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1069633
Modern Language Association (MLA)
Abdul Kadir, Noor Atiqah Aizan…[et al.]. Protective Effects of Tamarillo (Cyphomandra betacea) Extract against High Fat Diet Induced Obesity in Sprague-Dawley Rats. Journal of Obesity No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1069633
American Medical Association (AMA)
Abdul Kadir, Noor Atiqah Aizan& Rahmat, Asmah& Jaafar, Hawa Z. E.. Protective Effects of Tamarillo (Cyphomandra betacea) Extract against High Fat Diet Induced Obesity in Sprague-Dawley Rats. Journal of Obesity. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1069633
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1069633