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An Updated Meta-Analysis: Risk Conferred by Glutathione S-Transferases (GSTM1 and GSTT1) Polymorphisms to Age-Related Cataract
Joint Authors
Liao, Rong-feng
Ye, Min-jie
Liu, Cai-yuan
Ye, Dong-qing
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-01-27
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Purpose.
To study the effects of glutathione S-transferase M1 (GSTM1) and T1 (GSTT1) polymorphisms on age-related cataract (ARC).
Methods.
After a systematic literature search, all relevant studies evaluating the association between GSTs polymorphisms and ARC were included.
Results.
Fifteen studies on GSTM1 and nine studies on GSTT1 were included in this meta-analysis.
In the pooled analysis, a significant association between null genotype of GSTT1 and ARC was found (OR = 1.229, 95% CI = 1.057–1.429, and P=0.007).
In subgroup analysis, the association between cortical cataract (CC) and GSTM1 null genotype was statistically significant (OR = 0.713, 95% CI = 0.598–0.850, and P<0.001).
In addition, GSTM1 null genotype was significantly associated with ARC causing risk to individuals working indoors and not individuals working outdoors.
The association between GSTT1 null genotype and risk of ARC was statistically significant in Asians (OR = 1.442, 95% CI = 1.137–1.830, and P=0.003) but not in Caucasians.
Conclusions.
GSTM1 positive genotype is associated with increased risk of CC and loses the protective role in persons who work outdoors.
Considering the ethnic variation, GSTT1 null genotype is found to be associated with increased risk of ARC in Asians but not in Caucasians.
American Psychological Association (APA)
Liao, Rong-feng& Ye, Min-jie& Liu, Cai-yuan& Ye, Dong-qing. 2015. An Updated Meta-Analysis: Risk Conferred by Glutathione S-Transferases (GSTM1 and GSTT1) Polymorphisms to Age-Related Cataract. Journal of Ophthalmology،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1069640
Modern Language Association (MLA)
Liao, Rong-feng…[et al.]. An Updated Meta-Analysis: Risk Conferred by Glutathione S-Transferases (GSTM1 and GSTT1) Polymorphisms to Age-Related Cataract. Journal of Ophthalmology No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1069640
American Medical Association (AMA)
Liao, Rong-feng& Ye, Min-jie& Liu, Cai-yuan& Ye, Dong-qing. An Updated Meta-Analysis: Risk Conferred by Glutathione S-Transferases (GSTM1 and GSTT1) Polymorphisms to Age-Related Cataract. Journal of Ophthalmology. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1069640
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1069640