![](/images/graphics-bg.png)
Effects of Lutein and Zeaxanthin on LPS-Induced Secretion of IL-8 by Uveal Melanocytes and Relevant Signal Pathways
Joint Authors
Huang, Sheng-Chieh
Vagaggini, Tommaso
Chao, Shih-Chun
Nien, Chan-Wei
Lin, Hung-Yu
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-11-02
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
The effects of lutein and zeaxanthin on lipopolysaccharide- (LPS-) induced secretion of IL-8 by uveal melanocytes (UM) were tested in cultured human UM.
MTT assay revealed that LPS (0.01–1 μg/mL) and lutein and zeaxanthin (1–10 μM) did not influence the cell viability of cultured UM.
LPS caused a dose-dependent increase of secretion of IL-8 by cultured UM.
Lutein and zeaxanthin did not affect the constitutive secretion of IL-8.
However, lutein and zeaxanthin decreased LPS-induced secretion of IL-8 in cultured UM in a dose-dependent manner.
LPS significantly increased NF-κB levels in cell nuclear extracts and p-JNK levels in the cell lysates from UM, but not p-p38 MAPK and p-ERG.
Lutein or zeaxanthin significantly reduced LPS-induced increase of NF-κB and p-JNK levels, but not p38 MAPK and ERG levels.
The present study demonstrated that lutein and zeaxanthin inhibited LPS-induced secretion of IL-8 in cultured UM via JNK and NF-κB signal pathways.
The anti-inflammatory effects of lutein and zeaxanthin might be explored as a therapeutic approach in the management of uveitis and other inflammatory diseases of the eye.
American Psychological Association (APA)
Chao, Shih-Chun& Vagaggini, Tommaso& Nien, Chan-Wei& Huang, Sheng-Chieh& Lin, Hung-Yu. 2015. Effects of Lutein and Zeaxanthin on LPS-Induced Secretion of IL-8 by Uveal Melanocytes and Relevant Signal Pathways. Journal of Ophthalmology،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1069650
Modern Language Association (MLA)
Chao, Shih-Chun…[et al.]. Effects of Lutein and Zeaxanthin on LPS-Induced Secretion of IL-8 by Uveal Melanocytes and Relevant Signal Pathways. Journal of Ophthalmology No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1069650
American Medical Association (AMA)
Chao, Shih-Chun& Vagaggini, Tommaso& Nien, Chan-Wei& Huang, Sheng-Chieh& Lin, Hung-Yu. Effects of Lutein and Zeaxanthin on LPS-Induced Secretion of IL-8 by Uveal Melanocytes and Relevant Signal Pathways. Journal of Ophthalmology. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1069650
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1069650