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Effect of Glyceraldehyde Cross-Linking on a Rabbit Bullous Keratopathy Model
Author
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-10-05
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Background.
To evaluate the effects of corneal glyceraldehyde CXL on the rabbit bullous keratopathy models established by descemetorhexis.
Methods.
Fifteen rabbits were randomly divided into five groups.
Group A ( n = 3 ) is the control group.
The right eyes of animals in Groups B,C, D, and E ( n = 3 , resp.) were suffered with descemetorhexis procedures.
From the 8th day to the 14th day postoperatively, the right eyes in Groups C and D were instilled with hyperosmolar drops and glyceraldehyde drops, respectively; the right eyes in Group E were instilled with both hyperosmolar drops and glyceraldehyde drops.
Central corneal thickness (CCT), corneal transparency score, and histopathological analysis were applied on the eyes in each group.
Results.
Compared with Group A, statistically significant increase in CCT and corneal transparency score was found in Groups B, C, D, and E at 7 d postoperatively ( P < 0.05 ) and in Groups C, D, and E at 14 d postoperatively ( P < 0.05 ).
Conclusion.
Chemical CXL technique using glyceraldehyde improved the CCT and corneal transparency of the rabbit bullous keratopathy models.
Topical instillation with glyceraldehyde and hyperosmolar solutions seems to be a good choice for the bullous keratopathy treatment.
American Psychological Association (APA)
Wang, Mengmeng. 2015. Effect of Glyceraldehyde Cross-Linking on a Rabbit Bullous Keratopathy Model. Journal of Ophthalmology،Vol. 2015, no. 2015, pp.1-5.
https://search.emarefa.net/detail/BIM-1069659
Modern Language Association (MLA)
Wang, Mengmeng. Effect of Glyceraldehyde Cross-Linking on a Rabbit Bullous Keratopathy Model. Journal of Ophthalmology No. 2015 (2015), pp.1-5.
https://search.emarefa.net/detail/BIM-1069659
American Medical Association (AMA)
Wang, Mengmeng. Effect of Glyceraldehyde Cross-Linking on a Rabbit Bullous Keratopathy Model. Journal of Ophthalmology. 2015. Vol. 2015, no. 2015, pp.1-5.
https://search.emarefa.net/detail/BIM-1069659
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1069659