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Histone Deacetylases Inhibitors in the Treatment of Retinal Degenerative Diseases: Overview and Perspectives
Joint Authors
Zhang, Hua
Dai, Xufeng
Qi, Yan
He, Ying
Du, Wei
Pang, Ji-jing
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-06-02
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Retinal degenerative diseases are one of the important refractory ophthalmic diseases, featured with apoptosis of photoreceptor cells.
Histone acetylation and deacetylation can regulate chromosome assembly, gene transcription, and posttranslational modification, which are regulated by histone acetyltransferases (HATs) and histone deacetylases (HDACs), respectively.
The histone deacetylase inhibitors (HDACis) have the ability to cause hyperacetylation of histone and nonhistone proteins, resulting in a variety of effects on cell proliferation, differentiation, anti-inflammation, and anti-apoptosis.
Several HDACis have been approved for clinical trials to treat cancer.
Studies have shown that HDACis have neuroprotective effects in nervous system damage.
In this paper, we will summarize the neuroprotective effects of common HDACis in retinal degenerative diseases and make a prospect to the applications of HDACis in the treatment of retinal degenerative diseases in the future.
American Psychological Association (APA)
Zhang, Hua& Dai, Xufeng& Qi, Yan& He, Ying& Du, Wei& Pang, Ji-jing. 2015. Histone Deacetylases Inhibitors in the Treatment of Retinal Degenerative Diseases: Overview and Perspectives. Journal of Ophthalmology،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1069680
Modern Language Association (MLA)
Zhang, Hua…[et al.]. Histone Deacetylases Inhibitors in the Treatment of Retinal Degenerative Diseases: Overview and Perspectives. Journal of Ophthalmology No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1069680
American Medical Association (AMA)
Zhang, Hua& Dai, Xufeng& Qi, Yan& He, Ying& Du, Wei& Pang, Ji-jing. Histone Deacetylases Inhibitors in the Treatment of Retinal Degenerative Diseases: Overview and Perspectives. Journal of Ophthalmology. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1069680
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1069680