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ET-1 Plasma Levels, Aqueous Flare, and Choroidal Thickness in Patients with Retinitis Pigmentosa
Joint Authors
Strobbe, Ernesto
Fresina, Michela
Campos, Emilio C.
Cellini, Mauro
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-06-02
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Purpose.
To assess endothelin-1 (ET-1) plasma levels, choroidal thickness, and aqueous flare in patients with early stage retinitis pigmentosa (RP) and to search for possible correlations.
Methods.
We compared 24 RP patients with 24 healthy controls.
Choroidal thickness and aqueous flare were measured, respectively, by using a spectral domain optical coherence tomography and a laser flare-cell meter, whereas plasma samples were obtained from each patient to evaluate ET-1 plasma levels.
Results.
Notably, RP subjects showed significantly increased ET-1 plasma levels and reduced choroidal thickness compared with controls: 2.143 ± 0.258 versus 1.219 ± 0.236 pg/mL, P < 0.002 , and 226.75 ± 76.37 versus 303.9 ± 39.87 μm, P < 0.03 , respectively.
Higher aqueous flare values were also demonstrated in RP compared to controls: in detail, 10.51 ± 3.97 versus 5.66 ± 1.29 photon counts/ms, P < 0.0001 .
Spearman’s correlation test highlighted that the increase of ET-1 plasma levels was related with the decrease of choroidal thickness ( r = - 0.702 ; P < 0.023 ) and the increase of aqueous flare ( r = 0.580 ; P < 0.007 ).
Conclusions.
Early stage RP patients show a breakdown of blood-ocular barrier and increased ET-1 plasma levels and these findings may contribute to the reduction of choroidal thickness.
American Psychological Association (APA)
Strobbe, Ernesto& Cellini, Mauro& Fresina, Michela& Campos, Emilio C.. 2015. ET-1 Plasma Levels, Aqueous Flare, and Choroidal Thickness in Patients with Retinitis Pigmentosa. Journal of Ophthalmology،Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1069693
Modern Language Association (MLA)
Strobbe, Ernesto…[et al.]. ET-1 Plasma Levels, Aqueous Flare, and Choroidal Thickness in Patients with Retinitis Pigmentosa. Journal of Ophthalmology No. 2015 (2015), pp.1-6.
https://search.emarefa.net/detail/BIM-1069693
American Medical Association (AMA)
Strobbe, Ernesto& Cellini, Mauro& Fresina, Michela& Campos, Emilio C.. ET-1 Plasma Levels, Aqueous Flare, and Choroidal Thickness in Patients with Retinitis Pigmentosa. Journal of Ophthalmology. 2015. Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1069693
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1069693