The Relationship between Estimated Glomerular Filtration Rate and Diabetic Retinopathy

Abstract EN

Diabetic retinopathy (DR) is the leading cause of visual impairment and blindness in working-aged people.

Several studies have suggested that glomerular filtration rate (GFR) was correlated with DR.

This is a hospital-based study and the aim of it was to examine the relationship between the GFR and DR in patients with type 2 diabetes mellitus (T2DM).

We used CKD-EPI equation to estimate GFR and SPSS 19.0 and EmpowerStats software to assess their relationship.

Among the 1613 participants (aged 54.75 ± 12.19 years), 550 (34.1%) patients suffered from DR.

The multivariate analysis revealed that the risk factors for DR include age ( P < 0.001 , OR = 0.940), duration of diabetes ( P < 0.001 , OR = 1.163), hemoglobin A1c ( P = 0.007 , OR = 1.224), systolic blood pressure ( P < 0.001 , OR = 1.032), diastolic blood pressure ( P = 0.007 , OR = 0.953), high density lipoprotein cholesterol ( P = 0.024 , OR = 3.884), and eGFR ( P = 0.010 , OR = 0.973).

Through stratified analysis and saturation effect analysis, our data suggests that eGFR of 99.4 mL/min or lower might imply the early stage of DR in diabetic patients.

Thus, the evaluation of eGFR has clinical significance for the early diagnosis of DR.