Preservation of the Photoreceptor InnerOuter Segment Junction in Dry Age-Related Macular Degeneration Treated by Rheohemapheresis
Joint Authors
Langrová, Hana
Rencová, Eva
Renc, Ondřej
Stepanov, Alexander
Kratochvilová, Vera
Bláha, V.
Lánská, Miriam
Bláha, Milan
Studnička, Jan
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-08-17
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Aim.
To evaluate the long-term effect of rheohemapheresis (RHF) treatment of age-related macular degeneration (AMD) on photoreceptor IS/OS junction status.
Methods.
In our study, we followed 24 patients with dry AMD and drusenoid retinal pigment epithelium detachment (DPED) for a period of more than 2.5 years.
Twelve patients (22 eyes) were treated by RHF and 12 controls (18 eyes) were randomized.
The treated group underwent 8 RHF standardized procedures.
We evaluated best-corrected visual acuity, IS/OS junction status (SD OCT), and macular function (multifocal electroretinography) at baseline and at 2.5-year follow-up.
Results.
RHF caused a decrease of whole-blood viscosity/plasma viscosity at about 15/12%.
BCVA of treated patients increased insignificantly P=0.187 from median 74.0 letters (56.2 to 81.3 letters) to median 79.0 letters (57.3 to 83.4 letters), but it decreased significantly from 74.0 letters (25.2 to 82.6 letters) to 72.5 letters (23.4 to 83.1 letters) in the control group P=0.041.
The mfERG responses in the region of eccentricity between 1.8° and 7° were significantly higher in treated patients P=0.04.
Conclusions.
RHF contributed to sparing of photoreceptor IS/OS junction integrity in the fovea, which is assumed to be a predictive factor for preservation of visual acuity.
American Psychological Association (APA)
Rencová, Eva& Bláha, Milan& Studnička, Jan& Bláha, V.& Lánská, Miriam& Renc, Ondřej…[et al.]. 2015. Preservation of the Photoreceptor InnerOuter Segment Junction in Dry Age-Related Macular Degeneration Treated by Rheohemapheresis. Journal of Ophthalmology،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1069707
Modern Language Association (MLA)
Rencová, Eva…[et al.]. Preservation of the Photoreceptor InnerOuter Segment Junction in Dry Age-Related Macular Degeneration Treated by Rheohemapheresis. Journal of Ophthalmology No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1069707
American Medical Association (AMA)
Rencová, Eva& Bláha, Milan& Studnička, Jan& Bláha, V.& Lánská, Miriam& Renc, Ondřej…[et al.]. Preservation of the Photoreceptor InnerOuter Segment Junction in Dry Age-Related Macular Degeneration Treated by Rheohemapheresis. Journal of Ophthalmology. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1069707
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1069707