Effects of Zeaxanthin on Growth and Invasion of Human Uveal Melanoma in Nude Mouse Model
Joint Authors
Hu, Dan-Ning
Xu, Xiaoliang L.
Iacob, Codrin
Jordan, Adrienne
Gandhi, Sandipkumar
Gierhart, Dennis L.
Rosen, Richard
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-11-22
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Uveal melanoma cells were inoculated into the choroid of nude mice and treated with or without intraocular injection of zeaxanthin.
After 21 days, mice were sacrificed and the eyes enucleated.
Histopathological analysis was performed in hematoxylin and eosin stained frozen sections.
Melanoma developed rapidly in the control group (without treatment of zeaxanthin).
Tumor-bearing eye mass and tumor mass in the control group were significantly greater than those in zeaxanthin treated group.
Melanoma in the controlled eyes occupied a large part of the eye, was epithelioid in morphology, and was with numerous mitotic figures.
Scleral perforation and extraocular extension were observed in half of the eyes.
Melanomas in zeaxanthin treated eyes were significantly smaller with many necrosis and apoptosis areas and no extraocular extension could be found.
Quantitative image analysis revealed that the tumor size was reduced by 56% in eyes treated with low dosages of zeaxanthin and 92% in eyes treatment with high dosages of zeaxanthin, as compared to the controls.
This study demonstrated that zeaxanthin significantly inhibits the growth and invasion of human uveal melanoma in nude mice, suggesting that zeaxanthin may be a promising agent to be explored for the prevention and treatment of uveal melanoma.
American Psychological Association (APA)
Xu, Xiaoliang L.& Hu, Dan-Ning& Iacob, Codrin& Jordan, Adrienne& Gandhi, Sandipkumar& Gierhart, Dennis L.…[et al.]. 2015. Effects of Zeaxanthin on Growth and Invasion of Human Uveal Melanoma in Nude Mouse Model. Journal of Ophthalmology،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1069720
Modern Language Association (MLA)
Xu, Xiaoliang L.…[et al.]. Effects of Zeaxanthin on Growth and Invasion of Human Uveal Melanoma in Nude Mouse Model. Journal of Ophthalmology No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1069720
American Medical Association (AMA)
Xu, Xiaoliang L.& Hu, Dan-Ning& Iacob, Codrin& Jordan, Adrienne& Gandhi, Sandipkumar& Gierhart, Dennis L.…[et al.]. Effects of Zeaxanthin on Growth and Invasion of Human Uveal Melanoma in Nude Mouse Model. Journal of Ophthalmology. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1069720
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1069720