![](/images/graphics-bg.png)
Lutein Leads to a Decrease of Factor D Secretion by Cultured Mature Human Adipocytes
Joint Authors
Wabitsch, Martin
Kijlstra, Aize
Berendschot, Tos T. J. M.
Tian, Yuan
Renes, Johan
Webers, Carroll A. B.
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-10-04
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Purpose.
Complement plays an important role in the pathogenesis of age related macular degeneration (AMD) and trials are currently being conducted to investigate the effect of complement inhibition on AMD progression.
We previously found that the plasma level of factor D (FD), which is the rate limiting enzyme of the complement alternative pathway, was significantly decreased following lutein supplementation.
FD is synthesized by adipose tissue, which is also the main storage site of lutein.
In view of these findings we tested the hypothesis whether lutein could affect FD synthesis by adipocytes.
Methods.
A cell line of mature human adipocytes was incubated with 50 μg/mL lutein for 24 and 48 h, whereafter FD mRNA and protein expression were measured.
Results.
Lutein significantly inhibited adipocyte FD mRNA expression and FD protein release into adipocyte culture supernatants.
Conclusions.
Our earlier observations showing that a daily lutein supplement in individuals with early signs of AMD lowered the level of circulating FD might be caused by blocking adipocyte FD production.
American Psychological Association (APA)
Tian, Yuan& Kijlstra, Aize& Renes, Johan& Wabitsch, Martin& Webers, Carroll A. B.& Berendschot, Tos T. J. M.. 2015. Lutein Leads to a Decrease of Factor D Secretion by Cultured Mature Human Adipocytes. Journal of Ophthalmology،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1069740
Modern Language Association (MLA)
Tian, Yuan…[et al.]. Lutein Leads to a Decrease of Factor D Secretion by Cultured Mature Human Adipocytes. Journal of Ophthalmology No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1069740
American Medical Association (AMA)
Tian, Yuan& Kijlstra, Aize& Renes, Johan& Wabitsch, Martin& Webers, Carroll A. B.& Berendschot, Tos T. J. M.. Lutein Leads to a Decrease of Factor D Secretion by Cultured Mature Human Adipocytes. Journal of Ophthalmology. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1069740
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1069740