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Correlation of Vitreous Vascular Endothelial Growth Factor and Uric Acid Concentration Using Optical Coherence Tomography in Diabetic Macular Edema
Joint Authors
Kalousová, M.
Zima, T.
Krizova, Libuse
Kubena, Ales Antonin
Chrapek, Oldrich
Chrapkova, Barbora
Sin, Martin
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-11-17
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Purpose.
We investigated two factors linked to diabetic macular edema (DME), vitreous and serum levels of vascular endothelial growth factor (VEGF) and uric acid (UA) in patients with DME, and compared the results with changes in optical coherence tomography (OCT) and visual acuity (VA).
Methods.
A prospective study of 29 eyes, 16 cystoid DME and nonproliferative diabetic retinopathy (DR) and 13 nondiabetic controls.
Biochemical analysis of vitreous and serum samples was performed and OCT scans were graded according to central retinal thickness (CRT), cube volume (CV), cube average thickness (CAT), and serous retinal detachment (SRD).
Results.
In DME group, intravitreal concentrations of VEGF ( p < 0.001 ), UA ( p = 0.038 ), and total protein ( p < 0.001 ) were significantly higher than in control group.
In DME subjects, intravitreal UA correlated significantly with intravitreal VEGF (ƍ = 0.559, p = 0.03 ) but not with total vitreous protein and serum UA.
Increased intravitreal VEGF in DME group correlated with increase in CV (ƍ = 0.515/ p = 0.041 ).
None of the OCT parameters correlated with the VA.
Conclusions.
The results suggest that the CV might be assessor of anti-VEGF therapy efficacy.
Second, apart from VEGF, the role of UA in the pathogenesis and progression of DR should be considered.
American Psychological Association (APA)
Krizova, Libuse& Kalousová, M.& Kubena, Ales Antonin& Chrapek, Oldrich& Chrapkova, Barbora& Sin, Martin…[et al.]. 2015. Correlation of Vitreous Vascular Endothelial Growth Factor and Uric Acid Concentration Using Optical Coherence Tomography in Diabetic Macular Edema. Journal of Ophthalmology،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1069751
Modern Language Association (MLA)
Krizova, Libuse…[et al.]. Correlation of Vitreous Vascular Endothelial Growth Factor and Uric Acid Concentration Using Optical Coherence Tomography in Diabetic Macular Edema. Journal of Ophthalmology No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1069751
American Medical Association (AMA)
Krizova, Libuse& Kalousová, M.& Kubena, Ales Antonin& Chrapek, Oldrich& Chrapkova, Barbora& Sin, Martin…[et al.]. Correlation of Vitreous Vascular Endothelial Growth Factor and Uric Acid Concentration Using Optical Coherence Tomography in Diabetic Macular Edema. Journal of Ophthalmology. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1069751
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1069751