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Retinal Neurodegeneration in dbdb Mice at the Early Period of Diabetes
Joint Authors
Yang, Qin
Xu, Yidan
Xie, Ping
Cheng, Haixia
Song, Qinglu
Su, Tu
Yuan, Songtao
Liu, Qinghuai
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-03-02
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Purpose.
To describe both the functional and pathological alternations in neurosensory retina in a murine model of spontaneous type 2 diabetes (db/db mouse).
Methods.
db/db (BKS/DB−/−) mice and heterozygous littermates (as control group) at various ages (12, 16, 20, 24, and 28 weeks) were inspected with pattern electroretinogram (PERG), fundus fluorescein angiography (FFA), and optical coherence tomography (OCT).
Histological markers of neuroinflammation (IBA-1 and F4/80) were evaluated by immunohistochemistry.
In addition, levels of retinal ganglion cell death were measured by terminal dUTP nick-end labeling (TUNEL).
Results.
Significant alternations of PERG responses and increased retinal ganglion cells (RGCs) apoptosis were observed in diabetic db/db mice for 20-week period when compared with control group.
IBA-1 and F4/80 expression in microglia/macrophages became evidently for 24-week period, thus supporting the PERG findings.
Furthermore, obvious thinning of nasal and dorsal retina in 28-week-old db/db mice was also revealed by OCT.
No visible retinal microvascular changes were detected by FFA throughout the experiments on db/db mice.
Conclusions.
Diabetic retina underwent neurodegenerative changes in db/db mice, which happened at retinal ganglion cell layer and inner nuclear layer.
But there was no obvious abnormality in retinal vasculature on db/db mice.
American Psychological Association (APA)
Yang, Qin& Xu, Yidan& Xie, Ping& Cheng, Haixia& Song, Qinglu& Su, Tu…[et al.]. 2015. Retinal Neurodegeneration in dbdb Mice at the Early Period of Diabetes. Journal of Ophthalmology،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1069830
Modern Language Association (MLA)
Yang, Qin…[et al.]. Retinal Neurodegeneration in dbdb Mice at the Early Period of Diabetes. Journal of Ophthalmology No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1069830
American Medical Association (AMA)
Yang, Qin& Xu, Yidan& Xie, Ping& Cheng, Haixia& Song, Qinglu& Su, Tu…[et al.]. Retinal Neurodegeneration in dbdb Mice at the Early Period of Diabetes. Journal of Ophthalmology. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1069830
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1069830