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Prognostic Factors of Early Morphological Response to Treatment with Ranibizumab in Patients with Wet Age-Related Macular Degeneration
Joint Authors
Kolar, Petr
Dusek, Ladislav
Jarkovsky, Jiri
Chrapek, Oldrich
Chrapkova, Barbora
Sin, Martin
Studnička, Jan
Pitrová, Šárka
Řehák, Jiří
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-03-04
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Aim.
To assess the significance of age, gender, baseline best corrected visual acuity, baseline macula thickness, and type and size of choroidal neovascularization in early morphological therapeutic response to ranibizumab treatment in patients with the wet form of age-related macular degeneration.
Methods.
From 09/2008 to 06/2013 we evaluated 1153 newly diagnosed, treatment-naïve patients treated with ranibizumab.
Based on the morphological findings in the macula following the initial 3 injections of ranibizumab, the patients were divided into two groups based on active and inactive choroidal neovascularization.
Results.
After the initial 3 injections of ranibizumab, we examined the sample of 841 eyes with active CNV and 312 eyes with inactive CNV.
In the inactive group, we found a statistically higher proportion of occult CNV ( P < 0.001 ) and lower incidence of CNV greater than 5DA ( P < 0.001 ) compared with the active group.
We found no statistically significant difference in age, gender, baseline best corrected visual acuity, or baseline macula thickness between the inactive and active groups.
Conclusion.
Occult CNV and CNV smaller than 5DA are optimistic factors for a better morphological therapeutic response at the beginning of ranibizumab treatment.
American Psychological Association (APA)
Chrapek, Oldrich& Jarkovsky, Jiri& Sin, Martin& Studnička, Jan& Kolar, Petr& Chrapkova, Barbora…[et al.]. 2015. Prognostic Factors of Early Morphological Response to Treatment with Ranibizumab in Patients with Wet Age-Related Macular Degeneration. Journal of Ophthalmology،Vol. 2015, no. 2015, pp.1-4.
https://search.emarefa.net/detail/BIM-1069873
Modern Language Association (MLA)
Chrapek, Oldrich…[et al.]. Prognostic Factors of Early Morphological Response to Treatment with Ranibizumab in Patients with Wet Age-Related Macular Degeneration. Journal of Ophthalmology No. 2015 (2015), pp.1-4.
https://search.emarefa.net/detail/BIM-1069873
American Medical Association (AMA)
Chrapek, Oldrich& Jarkovsky, Jiri& Sin, Martin& Studnička, Jan& Kolar, Petr& Chrapkova, Barbora…[et al.]. Prognostic Factors of Early Morphological Response to Treatment with Ranibizumab in Patients with Wet Age-Related Macular Degeneration. Journal of Ophthalmology. 2015. Vol. 2015, no. 2015, pp.1-4.
https://search.emarefa.net/detail/BIM-1069873
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1069873