Association of MRS-Based Vertebral Bone Marrow Fat Fraction with Bone Strength in a Human In Vitro Model
Joint Authors
Burgkart, Rainer
Ruschke, Stefan
Gordijenko, Olga
Grande Garcia, Eduardo
Kooijman, Hendrik
Baum, Thomas
Rummeny, Ernst J.
Bauer, Jan S.
Karampinos, Dimitrios C.
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-04-19
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Bone marrow adiposity has recently gained attention due to its association with bone loss pathophysiology.
In this study, ten vertebrae were harvested from fresh human cadavers.
Trabecular BMD and microstructure parameters were extracted from MDCT.
Bone marrow fat fractions were determined using single-voxel MRS.
Failure load (FL) values were assessed by destructive biomechanical testing.
Significant correlations ( P < 0.05 ) were observed between MRS-based fat fraction and MDCT-based parameters (up to r = - 0.72 ) and MRS-based fat fraction and FL ( r = - 0.77 ).
These findings underline the importance of the bone marrow in the pathophysiology and imaging diagnostics of osteoporosis.
American Psychological Association (APA)
Karampinos, Dimitrios C.& Ruschke, Stefan& Gordijenko, Olga& Grande Garcia, Eduardo& Kooijman, Hendrik& Burgkart, Rainer…[et al.]. 2015. Association of MRS-Based Vertebral Bone Marrow Fat Fraction with Bone Strength in a Human In Vitro Model. Journal of Osteoporosis،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1069912
Modern Language Association (MLA)
Karampinos, Dimitrios C.…[et al.]. Association of MRS-Based Vertebral Bone Marrow Fat Fraction with Bone Strength in a Human In Vitro Model. Journal of Osteoporosis No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1069912
American Medical Association (AMA)
Karampinos, Dimitrios C.& Ruschke, Stefan& Gordijenko, Olga& Grande Garcia, Eduardo& Kooijman, Hendrik& Burgkart, Rainer…[et al.]. Association of MRS-Based Vertebral Bone Marrow Fat Fraction with Bone Strength in a Human In Vitro Model. Journal of Osteoporosis. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1069912
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1069912
