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Oral Calcidiol Is More Effective Than Cholecalciferol Supplementation to Reach Adequate 25(OH)D Levels in Patients with Autoimmune Diseases Chronically Treated with Low Doses of Glucocorticoids: A “Real-Life” Study
Joint Authors
Ortego-Jurado, Miguel
González-Moreno, Juan
González Ramírez, Amanda Rocío
González-Gay, Miguel A.
Ortego-Centeno, Norberto
Ríos-Fernández, Raquel
Callejas-Rubio, José Luis
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-06-01
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Glucocorticoids (GCs) are the cornerstone of the therapy in many autoimmune and inflammatory diseases.
However, it is well known that their use is a double edged sword, as their beneficial effects are associated almost universally with unwanted effects, as, for example glucocorticoid-induced osteoporosis (GIO).
Over the last years, several clinical practice guidelines emphasize the need of preventing bone mass loss and reduce the incidence of fractures associated with GC use.
Calcium and vitamin D supplementation, as adjunctive therapy, are included in all the practice guidelines.
However, no standard vitamin D dose has been established.
Several studies with postmenopausal women show that maintaining the levels above 30–33 ng/mL help improve the response to bisphosphonates.
It is unknown if the response is the same in GIO, but in the clinical practice the levels are maintained at around the same values.
In this study we demonstrate that patients with autoimmune diseases, undergoing glucocorticoid therapy, often present suboptimal 25(OH)D levels.
Patients with higher body mass index and those receiving higher doses of glucocorticoids are at increased risk of having lower levels of 25(OH)D.
In these patients, calcidiol supplementations are more effective than cholecalciferol to reach adequate 25(OH)D levels.
American Psychological Association (APA)
Ortego-Jurado, Miguel& Callejas-Rubio, José Luis& Ríos-Fernández, Raquel& González-Moreno, Juan& González Ramírez, Amanda Rocío& González-Gay, Miguel A.…[et al.]. 2015. Oral Calcidiol Is More Effective Than Cholecalciferol Supplementation to Reach Adequate 25(OH)D Levels in Patients with Autoimmune Diseases Chronically Treated with Low Doses of Glucocorticoids: A “Real-Life” Study. Journal of Osteoporosis،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1069920
Modern Language Association (MLA)
Ortego-Jurado, Miguel…[et al.]. Oral Calcidiol Is More Effective Than Cholecalciferol Supplementation to Reach Adequate 25(OH)D Levels in Patients with Autoimmune Diseases Chronically Treated with Low Doses of Glucocorticoids: A “Real-Life” Study. Journal of Osteoporosis No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1069920
American Medical Association (AMA)
Ortego-Jurado, Miguel& Callejas-Rubio, José Luis& Ríos-Fernández, Raquel& González-Moreno, Juan& González Ramírez, Amanda Rocío& González-Gay, Miguel A.…[et al.]. Oral Calcidiol Is More Effective Than Cholecalciferol Supplementation to Reach Adequate 25(OH)D Levels in Patients with Autoimmune Diseases Chronically Treated with Low Doses of Glucocorticoids: A “Real-Life” Study. Journal of Osteoporosis. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1069920
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1069920