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No Polymorphism in Plasmodium falciparum K13 Propeller Gene in Clinical Isolates from Kolkata, India
Joint Authors
Das, Madhusudan
Chatterjee, Moytrey
Ganguly, Swagata
Saha, Pabitra
Bankura, Biswabandhu
Basu, Nandita
Guha, Subhasish K.
Maji, Ardhendu K.
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-11-25
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Molecular markers associated with artemisinin resistance in Plasmodium falciparum are yet to be well defined.
Recent studies showed that polymorphisms in K13 gene are associated with artemisinin resistance.
The present study was designed to know the pattern of polymorphisms in propeller region of K13 gene among the clinical isolates collected from urban Kolkata after five years of ACT implementation.
We collected 59 clinical isolates from urban Kolkata and sequenced propeller region of K13 gene in 51 isolates successfully.
We did not find any mutation in any isolate.
All patients responded to the ACT, a combination of artesunate + sulphadoxine-pyrimethamine.
The drug regimen is still effective in the study area and there is no sign of emergence of resistance against artemisinin as evidenced by wild genotype of K13 gene in all isolates studied.
American Psychological Association (APA)
Chatterjee, Moytrey& Ganguly, Swagata& Saha, Pabitra& Bankura, Biswabandhu& Basu, Nandita& Das, Madhusudan…[et al.]. 2015. No Polymorphism in Plasmodium falciparum K13 Propeller Gene in Clinical Isolates from Kolkata, India. Journal of Pathogens،Vol. 2015, no. 2015, pp.1-4.
https://search.emarefa.net/detail/BIM-1069942
Modern Language Association (MLA)
Chatterjee, Moytrey…[et al.]. No Polymorphism in Plasmodium falciparum K13 Propeller Gene in Clinical Isolates from Kolkata, India. Journal of Pathogens No. 2015 (2015), pp.1-4.
https://search.emarefa.net/detail/BIM-1069942
American Medical Association (AMA)
Chatterjee, Moytrey& Ganguly, Swagata& Saha, Pabitra& Bankura, Biswabandhu& Basu, Nandita& Das, Madhusudan…[et al.]. No Polymorphism in Plasmodium falciparum K13 Propeller Gene in Clinical Isolates from Kolkata, India. Journal of Pathogens. 2015. Vol. 2015, no. 2015, pp.1-4.
https://search.emarefa.net/detail/BIM-1069942
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1069942