Evaluation of Antibiotic Susceptibility of Gram-Positive Anaerobic Cocci Isolated from Cancer Patients of the N. N. Blokhin Russian Cancer Research Center

Abstract EN

In total, 81 nonduplicate gram-positive anaerobic cocci (GPAC) were involved in this study.

The GPAC were isolated from samples collected from cancer patients between 2004 and 2014.

Species identification was carried out by matrix-assisted laser desorption ionization time of flight mass spectrometry (MALDI-TOF MS).

The majority of isolates were identified as Finegoldia magna (47%) and Peptoniphilus harei (28%).

The susceptibility of six species of GPAC was determined for eight antibiotics according to E-test methodology.

Furthermore, all isolates were susceptible to imipenem, vancomycin, and linezolid.

Susceptibility to penicillin G, amoxicillin/clavulanate, metronidazole, ciprofloxacin, and levofloxacin varied for different species.

One Finegoldia magna isolate was multidrug-resistant (i.e., parallel resistance to five antimicrobial agents, including metronidazole, was observed).

Two Parvimonas micra isolates were highly resistant to metronidazole (MIC 256 μg/mL) but were sensitive to other tested antibiotics.