Protective Effects of Tinospora crispa Stem Extract on Renal Damage and Hemolysis during Plasmodium berghei Infection in Mice
Joint Authors
Somsak, Voravuth
Nutham, Narain
Sakulmettatham, Sakuna
Klongthalay, Suwit
Chutoam, Palatip
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-10-27
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Renal damage and hemolysis induced by malaria are associated with mortality in adult patients.
It has been speculated that oxidative stress condition induced by malaria infection is involved in its pathology.
Thus, we aimed to investigate the protective effects of Tinospora crispa stem extract on renal damage and hemolysis during Plasmodium berghei infection.
T.
crispa stem extract was prepared using hot water method and used for oral treatment in mice.
Groups of ICR mice were infected with 1 × 10 7 parasitized erythrocytes of P.
berghei ANKA by intraperitoneal injection and given the extracts (500, 1000, and 2000 mg/kg) twice a day for 4 consecutive days.
To assess renal damage and hemolysis, blood urea nitrogen (BUN), creatinine, and hematocrit (%Hct) levels were then evaluated, respectively.
Malaria infection resulted in renal damage and hemolysis as indicated by increasing of BUN and creatinine and decreasing of %Hct, respectively.
However, protective effects on renal damage and hemolysis were observed in infected mice treated with these extracts at doses of 1000 and 2000 mg/kg.
In conclusion, T.
crispa stem extract exerted protective effects on renal damage and hemolysis induced by malaria infection.
This plant may work as potential source in the development of variety of herbal formulations for malarial treatment.
American Psychological Association (APA)
Nutham, Narain& Sakulmettatham, Sakuna& Klongthalay, Suwit& Chutoam, Palatip& Somsak, Voravuth. 2015. Protective Effects of Tinospora crispa Stem Extract on Renal Damage and Hemolysis during Plasmodium berghei Infection in Mice. Journal of Pathogens،Vol. 2015, no. 2015, pp.1-5.
https://search.emarefa.net/detail/BIM-1069951
Modern Language Association (MLA)
Nutham, Narain…[et al.]. Protective Effects of Tinospora crispa Stem Extract on Renal Damage and Hemolysis during Plasmodium berghei Infection in Mice. Journal of Pathogens No. 2015 (2015), pp.1-5.
https://search.emarefa.net/detail/BIM-1069951
American Medical Association (AMA)
Nutham, Narain& Sakulmettatham, Sakuna& Klongthalay, Suwit& Chutoam, Palatip& Somsak, Voravuth. Protective Effects of Tinospora crispa Stem Extract on Renal Damage and Hemolysis during Plasmodium berghei Infection in Mice. Journal of Pathogens. 2015. Vol. 2015, no. 2015, pp.1-5.
https://search.emarefa.net/detail/BIM-1069951
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1069951