![](/images/graphics-bg.png)
Susceptibility Pattern and Distribution of Oxacillinases and bla PER-1 Genes among Multidrug Resistant Acinetobacter baumannii in a Teaching Hospital in Iran
Joint Authors
Moniri, Rezvan
Bagheri Josheghani, Sareh
Sehat, Mojtaba
Dasteh Goli, Yasaman
Firoozeh, Farzaneh
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-12-31
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Acinetobacter baumannii (A.
baumannii) is an important nosocomial pathogen in healthcare institutions.
β-Lactamase-mediated resistance is the most common mechanism for carbapenem resistance in A.
baumannii.
The aim of this study was to determine the antibiotic resistance pattern, to detect OXA encoding genes, class A, b l a P E R - 1 , and to detect the presence of ISAba1.
A total of 124 A.
baumannii isolates were collected from hospitalized patients in a teaching hospital in Kashan, Iran.
The susceptibility of isolates to different antibiotics was determined by disk-diffusion method.
PCR was used to detect b l a P E R - 1 , b l a O X A - 23 , b l a O X A - 24 , b l a O X A - 51 , b l a O X A - 58 , and ISAba1 genes.
All isolates were resistant to ceftazidime, ceftriaxone, and cefotaxime.
All of the isolates revealed susceptibility to polymyxin B and colistin.
Ninety-six percent of the isolates were extensive drug resistance (XDR), 5.6% extended spectrum beta-lactamase (ESBL), and 54.8% metallo-beta-lactamase (MBL).
All isolates were positive for b l a O X A - 51 and ISAba1.
b l a O X A - 23 , b l a O X A - 24 , and b l a O X A - 58 were found in 79.8%, 25%, and 3.2%, respectively.
The frequency rate of b l a P E R - 1 gene was 52.4%.
Multidrug resistant A.
baumannii isolates are increasing in our setting and extensively limit therapeutic options.
The high rate presence of class D carbapenemase-encoding genes, mainly b l a O X A - 23 carbapenemases, is worrying and alarming as an emerging threat in our hospital.
American Psychological Association (APA)
Bagheri Josheghani, Sareh& Moniri, Rezvan& Firoozeh, Farzaneh& Sehat, Mojtaba& Dasteh Goli, Yasaman. 2015. Susceptibility Pattern and Distribution of Oxacillinases and bla PER-1 Genes among Multidrug Resistant Acinetobacter baumannii in a Teaching Hospital in Iran. Journal of Pathogens،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1069956
Modern Language Association (MLA)
Bagheri Josheghani, Sareh…[et al.]. Susceptibility Pattern and Distribution of Oxacillinases and bla PER-1 Genes among Multidrug Resistant Acinetobacter baumannii in a Teaching Hospital in Iran. Journal of Pathogens No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1069956
American Medical Association (AMA)
Bagheri Josheghani, Sareh& Moniri, Rezvan& Firoozeh, Farzaneh& Sehat, Mojtaba& Dasteh Goli, Yasaman. Susceptibility Pattern and Distribution of Oxacillinases and bla PER-1 Genes among Multidrug Resistant Acinetobacter baumannii in a Teaching Hospital in Iran. Journal of Pathogens. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1069956
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1069956