Effectiveness of Intermittent Preventive Treatment in Pregnancy with Sulphadoxine-Pyrimethamine against Submicroscopic falciparum Malaria in Central Region, Ghana
Joint Authors
Orish, Verner Ndudiri
Nwaefuna, Ekene K.
Afoakwah, Richmond
Egyir-Yawson, Alexander
Boampong, J. N.
Source
Journal of Parasitology Research
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-09-13
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Malaria infections undetectable by microscopy but detectable by Polymerase Chain Reaction (PCR) (submicroscopic malaria) are common in endemic areas like Ghana.
Submicroscopic malaria has been linked with severe pregnancy outcomes as well as contributing to malaria transmission.
In this cross-sectional study 872 consenting pregnant women (gestation ≥ 20 weeks) were recruited from 8 hospitals in Central Region, Ghana, between July and December 2009.
Malaria infection was detected by microscopy and PCR.
Haemoglobin was measured and anaemia was defined as haemoglobin lower than 11 g/dL.
Majority of the women, 555 (63.6%), were Intermittent Preventive Treatment in Pregnancy with Sulphadoxine-Pyrimethamine (IPTp-SP) users while 234 (36.4%) were nonusers.
The prevalence of malaria by microscopy was 20.9% (182/872) and 9.7% (67/688) of microscopy negative women had submicroscopic malaria.
IPTp-SP usage significantly (odds ratio = 0.13, 95% confidence interval = 0.07–0.23, p=0.005) reduced the prevalence of submicroscopic malaria as more nonusers (51/234) than users (16/454) were PCR positive.
After controlling for other variables the effect of IPTp-SP remained statistically significant (odds ratio = 0.11, 95% confidence interval = 0.02–0.22, p=0.006).
These results suggest that Intermittent Preventive Treatment with Sulphadoxine-Pyrimethamine is useful in the reduction of submicroscopic malaria in pregnancy.
American Psychological Association (APA)
Nwaefuna, Ekene K.& Afoakwah, Richmond& Orish, Verner Ndudiri& Egyir-Yawson, Alexander& Boampong, J. N.. 2015. Effectiveness of Intermittent Preventive Treatment in Pregnancy with Sulphadoxine-Pyrimethamine against Submicroscopic falciparum Malaria in Central Region, Ghana. Journal of Parasitology Research،Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1069979
Modern Language Association (MLA)
Nwaefuna, Ekene K.…[et al.]. Effectiveness of Intermittent Preventive Treatment in Pregnancy with Sulphadoxine-Pyrimethamine against Submicroscopic falciparum Malaria in Central Region, Ghana. Journal of Parasitology Research No. 2015 (2015), pp.1-6.
https://search.emarefa.net/detail/BIM-1069979
American Medical Association (AMA)
Nwaefuna, Ekene K.& Afoakwah, Richmond& Orish, Verner Ndudiri& Egyir-Yawson, Alexander& Boampong, J. N.. Effectiveness of Intermittent Preventive Treatment in Pregnancy with Sulphadoxine-Pyrimethamine against Submicroscopic falciparum Malaria in Central Region, Ghana. Journal of Parasitology Research. 2015. Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1069979
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1069979