Highly Sensitive Electrochemical Sensor for the Determination of 8-Hydroxy-2′-deoxyguanosine Incorporating SWCNTs-Nafion Composite Film
Joint Authors
Li, Chenzhong
Yang, Lingfei
Wang, Bing
Qi, Honglan
Gao, Qiang
Zhang, Chengxiao
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-09-13
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
8-Hydroxy-2′-deoxyguanosine (8-OHdG) is a typical biomarker of oxidative DNA damage and has attracted much attention in recent years since the level of 8-OHdG in body fluids is typically associated with various diseases.
In this work, a simple and highly sensitive electrochemical sensor for the determination of 8-OHdG was fabricated incorporating single wall carbon nanotubes- (SWCNTs-) Nafion composite film coated on glassy carbon electrode.
Nafion was chosen as an optimal adhesive agent from a series of adhesive agents and acted as a binder, enrichment, and exclusion film.
Due to the strong cation-exchange ability of Nafion and the outstanding electronic properties of SWCNTs, the prepared SWCNTs-Nafion film can strongly enhance the electrochemical response to oxidation of 8-OHdG and efficiently alleviate the interferences from uric acid and ascorbic acid.
The oxidation peak currents are linear with the concentration of 8-OHdG in the range of 0.03 to 1.25 μM with a detection limit of 8.0 nM (S/N = 3).
This work demonstrates that SWCNTs-Nafion film can improve the sensitivity, selectivity, reproducibility, and stability, making it an ideal candidate for electrochemical detection of 8-OHdG.
American Psychological Association (APA)
Yang, Lingfei& Wang, Bing& Qi, Honglan& Gao, Qiang& Li, Chenzhong& Zhang, Chengxiao. 2015. Highly Sensitive Electrochemical Sensor for the Determination of 8-Hydroxy-2′-deoxyguanosine Incorporating SWCNTs-Nafion Composite Film. Journal of Sensors،Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1070137
Modern Language Association (MLA)
Yang, Lingfei…[et al.]. Highly Sensitive Electrochemical Sensor for the Determination of 8-Hydroxy-2′-deoxyguanosine Incorporating SWCNTs-Nafion Composite Film. Journal of Sensors No. 2015 (2015), pp.1-11.
https://search.emarefa.net/detail/BIM-1070137
American Medical Association (AMA)
Yang, Lingfei& Wang, Bing& Qi, Honglan& Gao, Qiang& Li, Chenzhong& Zhang, Chengxiao. Highly Sensitive Electrochemical Sensor for the Determination of 8-Hydroxy-2′-deoxyguanosine Incorporating SWCNTs-Nafion Composite Film. Journal of Sensors. 2015. Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1070137
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1070137