Intoxication by Cyanide in Pregnant Sows: Prenatal and Postnatal Evaluation
Joint Authors
Maiorka, Paulo
Gotardo, André T.
Hueza, Isis M.
Manzano, Helena
Maruo, Viviane M.
Górniak, Silvana L.
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-05-26
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Cyanide is a ubiquitous chemical in the environment and has been associated with many intoxication episodes; however, little is known about its potentially toxic effects on development.
The aim of this study was to evaluate the effects of maternal exposure to potassium cyanide (KCN) during pregnancy on both sows and their offspring.
Twenty-four pregnant sows were allocated into four groups that orally received different doses of KCN (0.0, 2.0, 4.0, and 6.0 mg/kg of body weight) from day 21 of pregnancy to term.
The KCN-treated sows showed histological lesions in the CNS, thyroid follicle enlargement, thyroid epithelial thickening, colloid reabsorption changes, and vacuolar degeneration of the renal tubular epithelium.
Sows treated with 4.0 mg/kg KCN showed an increase in the number of dead piglets at birth.
Weaned piglets from all KCN-treated groups showed histological lesions in the thyroid glands with features similar to those found in their mothers.
The exposure of pregnant sows to cyanide thus caused toxic effects in both mothers and piglets.
We suggest that swine can serve as a useful animal model to assess the neurological, goitrogenic, and reproductive effects of cyanide toxicosis.
American Psychological Association (APA)
Gotardo, André T.& Hueza, Isis M.& Manzano, Helena& Maruo, Viviane M.& Maiorka, Paulo& Górniak, Silvana L.. 2015. Intoxication by Cyanide in Pregnant Sows: Prenatal and Postnatal Evaluation. Journal of Toxicology،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1070371
Modern Language Association (MLA)
Gotardo, André T.…[et al.]. Intoxication by Cyanide in Pregnant Sows: Prenatal and Postnatal Evaluation. Journal of Toxicology No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1070371
American Medical Association (AMA)
Gotardo, André T.& Hueza, Isis M.& Manzano, Helena& Maruo, Viviane M.& Maiorka, Paulo& Górniak, Silvana L.. Intoxication by Cyanide in Pregnant Sows: Prenatal and Postnatal Evaluation. Journal of Toxicology. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1070371
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1070371