Antimicrobial Activities of a Plethora of Medicinal Plant Extracts and Hydrolates against Human Pathogens and Their Potential to Reverse Antibiotic Resistance
Joint Authors
Njimoh, Dieudonné Lemuh
Assob, Jules Clement N.
Mokake, Seraphine Ebenye
Nyhalah, Dinga Jerome
Yinda, Claude Kwe
Sandjon, Bertrand
Source
International Journal of Microbiology
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-05-27
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Microbial infections till date remain a scourge of humanity due to lack of vaccine against some infections, emergence of drug resistant phenotypes, and the resurgence of infections amongst others.
Continuous quest for novel therapeutic approaches remains imperative.
Here we (i) assessed the effects of extracts/hydrolates of some medicinal plants on pathogenic microorganisms and (ii) evaluated the inhibitory potential of the most active ones in combination with antibiotics.
Extract E03 had the highest DZI (25 mm).
Extracts E05 and E06 were active against all microorganisms tested.
The MICs and MBCs of the methanol extracts ranged from 16.667 × 103 μg/mL to 2 μg/mL and hydrolates from 0.028 to 333333 ppm.
Extract E30 had the highest activity especially against S.
saprophyticus (MIC of 6 ppm) and E.
coli (MIC of 17 ppm).
Combination with conventional antibiotics was shown to overcome resistance especially with E30.
Analyses of the extracts revealed the presence of alkaloids, flavonoids, triterpenes, steroids, phenols, and saponins.
These results justify the use of these plants in traditional medicine and the practice of supplementing decoctions/concoctions with conventional antibiotics.
Nauclea pobeguinii (E30), the most active and synergistic of all these extracts, and some hydrolates with antimicrobial activity need further exploration for the development of novel antimicrobials.
American Psychological Association (APA)
Njimoh, Dieudonné Lemuh& Assob, Jules Clement N.& Mokake, Seraphine Ebenye& Nyhalah, Dinga Jerome& Yinda, Claude Kwe& Sandjon, Bertrand. 2015. Antimicrobial Activities of a Plethora of Medicinal Plant Extracts and Hydrolates against Human Pathogens and Their Potential to Reverse Antibiotic Resistance. International Journal of Microbiology،Vol. 2015, no. 2015, pp.1-15.
https://search.emarefa.net/detail/BIM-1070379
Modern Language Association (MLA)
Njimoh, Dieudonné Lemuh…[et al.]. Antimicrobial Activities of a Plethora of Medicinal Plant Extracts and Hydrolates against Human Pathogens and Their Potential to Reverse Antibiotic Resistance. International Journal of Microbiology No. 2015 (2015), pp.1-15.
https://search.emarefa.net/detail/BIM-1070379
American Medical Association (AMA)
Njimoh, Dieudonné Lemuh& Assob, Jules Clement N.& Mokake, Seraphine Ebenye& Nyhalah, Dinga Jerome& Yinda, Claude Kwe& Sandjon, Bertrand. Antimicrobial Activities of a Plethora of Medicinal Plant Extracts and Hydrolates against Human Pathogens and Their Potential to Reverse Antibiotic Resistance. International Journal of Microbiology. 2015. Vol. 2015, no. 2015, pp.1-15.
https://search.emarefa.net/detail/BIM-1070379
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1070379