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Acute β-N-Methylamino-L-alanine Toxicity in a Mouse Model
Joint Authors
Al-Sammak, Maitham Ahmed
Rogers, Douglas G.
Hoagland, Kyle D.
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-10-29
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The cyanobacterial neurotoxin β-N-methylamino-L-alanine (BMAA) is considered to be an “excitotoxin,” and its suggested mechanism of action is killing neurons.
Long-term exposure to L-BMAA is believed to lead to neurodegenerative diseases including Parkinson’s and Alzheimer’s diseases and amyotrophic lateral sclerosis (Lou Gehrig’s disease).
Objectives of this study were to determine the presumptive median lethal dose (LD50), the Lowest-Observed-Adverse-Effect Level (LOAEL), and histopathologic lesions caused by the naturally occurring BMAA isomer, L-BMAA, in mice.
Seventy NIH Swiss Outbred mice (35 male and 35 female) were used.
Treatment group mice were injected intraperitoneally with 0.03, 0.3, 1, 2, and 3 mg/g body weight L-BMAA, respectively, and control mice were sham-injected.
The presumptive LD50 of L-BMAA was 3 mg/g BW and the LOAEL was 2 mg/g BW.
There were no histopathologic lesions in brain, liver, heart, kidney, lung, or spleen in any of the mice during the 14-day study.
L-BMAA was detected in brains and livers in all of treated mice but not in control mice.
Males injected with 0.03 mg/g BW, 0.3 mg/g BW, and 3.0 mg/g BW L-BMAA showed consistently higher concentrations (P < 0.01) in brain and liver samples as compared to females in those respective groups.
American Psychological Association (APA)
Al-Sammak, Maitham Ahmed& Rogers, Douglas G.& Hoagland, Kyle D.. 2015. Acute β-N-Methylamino-L-alanine Toxicity in a Mouse Model. Journal of Toxicology،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1070388
Modern Language Association (MLA)
Al-Sammak, Maitham Ahmed…[et al.]. Acute β-N-Methylamino-L-alanine Toxicity in a Mouse Model. Journal of Toxicology No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1070388
American Medical Association (AMA)
Al-Sammak, Maitham Ahmed& Rogers, Douglas G.& Hoagland, Kyle D.. Acute β-N-Methylamino-L-alanine Toxicity in a Mouse Model. Journal of Toxicology. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1070388
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1070388