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Adherence to Artemisinin-Based Combination Therapy for the Treatment of Uncomplicated Malaria: A Systematic Review and Meta-Analysis
Joint Authors
Dalhat, Mahmood M.
Muhammad, Hamza
Yakasai, Ahmad M.
Bello, Musa
Gadanya, Muktar A.
Yaqub, Zuwaira M.
Ibrahim, Daiyabu A.
Hassan-Hanga, Fatimah
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-05-28
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Adherence to artemisinin-based combination therapy (ACT) is not clearly defined.
This meta-analysis determines the prevalence and predictors of adherence to ACT.
Twenty-five studies and six substudies met the inclusion criteria.
The prevalence of ACT adherence in the public sector was significantly higher compared to retail sector (76% and 45%, resp., P < 0.0001 ).
However, ACT adherence was similar across different ACT dosing regimens and formulations.
In metaregression analysis prevalence estimates of adherence significantly decrease with increasing year of study publication P = 0.046 .
Factors found to be significant predictors of ACT adherence were years of education ≥ 7 { odds ratio (OR) (95% CI) = 1.63 (1.05–2.53) } , higher income { 2.0 (1.35–2.98) } , fatty food { 4.6 (2.49–8.50) } , exact number of pills dispensed { 4.09 (1.60–10.7) } , and belief in traditional medication for malaria { 0.09 (0.01–0.78) } .
The accuracy of pooled estimates could be limited by publication bias, and differing methods and thresholds of assessing adherence.
To improve ACT adherence, educational programs to increase awareness and understanding of ACT dosing regimen are interventions urgently needed.
Patients and caregivers should be provided with an adequate explanation at the time of prescribing and/or dispensing ACT.
American Psychological Association (APA)
Yakasai, Ahmad M.& Muhammad, Hamza& Dalhat, Mahmood M.& Bello, Musa& Gadanya, Muktar A.& Yaqub, Zuwaira M.…[et al.]. 2015. Adherence to Artemisinin-Based Combination Therapy for the Treatment of Uncomplicated Malaria: A Systematic Review and Meta-Analysis. Journal of Tropical Medicine،Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1070395
Modern Language Association (MLA)
Yakasai, Ahmad M.…[et al.]. Adherence to Artemisinin-Based Combination Therapy for the Treatment of Uncomplicated Malaria: A Systematic Review and Meta-Analysis. Journal of Tropical Medicine No. 2015 (2015), pp.1-11.
https://search.emarefa.net/detail/BIM-1070395
American Medical Association (AMA)
Yakasai, Ahmad M.& Muhammad, Hamza& Dalhat, Mahmood M.& Bello, Musa& Gadanya, Muktar A.& Yaqub, Zuwaira M.…[et al.]. Adherence to Artemisinin-Based Combination Therapy for the Treatment of Uncomplicated Malaria: A Systematic Review and Meta-Analysis. Journal of Tropical Medicine. 2015. Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1070395
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1070395