Clinical Presentation, Aetiology, and Outcomes of Meningitis in a Setting of High HIV and TB Prevalence
Joint Authors
Thinyane, Keneuoe Hycianth
Motsemme, Keanole Mofona
Cooper, Varsay Jim Lahai
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-09-30
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Meningitis causes significant morbidity and mortality globally.
The aim of this study was to study the clinical presentation, aetiology, and outcomes of meningitis among adult patients admitted to Queen Mamohato Memorial Hospital in Maseru, Lesotho, with a diagnosis of meningitis.
A cross-sectional study was conducted between February and April 2014; data collected included presenting signs and symptoms, laboratory results, and clinical outcomes.
Descriptive statistics were used to summarise data; association between variables was analysed using Fisher’s exact test.
56 patients were enrolled; the HIV coinfection rate was 79%.
The most common presenting symptoms were altered mental status, neck stiffness, headache, and fever.
TB meningitis was the most frequent diagnosis (39%), followed by bacterial (27%), viral (18%), and cryptococcal meningitis (16%).
In-hospital mortality was 43% with case fatalities of 23%, 40%, 44%, and 90% for TB, bacterial, cryptococcal, and viral meningitis, respectively.
Severe renal impairment was significantly associated with mortality.
In conclusion, the causes of meningitis in this study reflect the high prevalence of HIV and TB in our setting.
Strategies to reduce morbidity and mortality due to meningitis should include improving diagnostic services to facilitate early detection and treatment of meningitis and timely initiation of antiretroviral therapy in HIV-infected patients.
American Psychological Association (APA)
Thinyane, Keneuoe Hycianth& Motsemme, Keanole Mofona& Cooper, Varsay Jim Lahai. 2015. Clinical Presentation, Aetiology, and Outcomes of Meningitis in a Setting of High HIV and TB Prevalence. Journal of Tropical Medicine،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1070403
Modern Language Association (MLA)
Thinyane, Keneuoe Hycianth…[et al.]. Clinical Presentation, Aetiology, and Outcomes of Meningitis in a Setting of High HIV and TB Prevalence. Journal of Tropical Medicine No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1070403
American Medical Association (AMA)
Thinyane, Keneuoe Hycianth& Motsemme, Keanole Mofona& Cooper, Varsay Jim Lahai. Clinical Presentation, Aetiology, and Outcomes of Meningitis in a Setting of High HIV and TB Prevalence. Journal of Tropical Medicine. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1070403
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1070403