Antibiotic Resistance in Streptococcus pneumoniae after Azithromycin Distribution for Trachoma
Joint Authors
Ho, Derek K-H.
Sawicki, Christian
Grassly, Nicholas
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-10-18
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Trachoma is caused by Chlamydia trachomatis and is a leading cause of blindness worldwide.
Mass distribution of azithromycin (AZM) is part of the strategy for the global elimination of blinding trachoma by 2020.
Although resistance to AZM in C.
trachomatis has not been reported, there have been concerns about resistance in other organisms when AZM is administered in community settings.
We identified studies that measured pneumococcal prevalence and resistance to AZM following mass AZM provision reported up to 2013 in Medline and Web of Science databases.
Potential sources of bias were assessed using the Cochrane Risk of Bias Tool.
A total of 45 records were screened, of which 8 met the inclusion criteria.
We identified two distinct trends of resistance prevalence, which are dependent on frequency of AZM provision and baseline prevalence of resistance.
We also demonstrated strong correlation between the prevalence of resistance at baseline and at 2-3 months ( r = 0.759 ).
Although resistance to AZM in C.
trachomatis has not been reported, resistance to this commonly used macrolide antibiotic in other diseases could compromise treatment.
This should be considered when planning long-term trachoma control strategies.
American Psychological Association (APA)
Ho, Derek K-H.& Sawicki, Christian& Grassly, Nicholas. 2015. Antibiotic Resistance in Streptococcus pneumoniae after Azithromycin Distribution for Trachoma. Journal of Tropical Medicine،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1070417
Modern Language Association (MLA)
Ho, Derek K-H.…[et al.]. Antibiotic Resistance in Streptococcus pneumoniae after Azithromycin Distribution for Trachoma. Journal of Tropical Medicine No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1070417
American Medical Association (AMA)
Ho, Derek K-H.& Sawicki, Christian& Grassly, Nicholas. Antibiotic Resistance in Streptococcus pneumoniae after Azithromycin Distribution for Trachoma. Journal of Tropical Medicine. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1070417
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1070417